MATH+ Protocol for COVID-19 and Dr Paul Marik
The MATH+ Protocol Story January, 2020. Dr. Paul E. Marik, Professor of Medicine and Chief of the Division of Pulmonary and Critical Care Medicine at the Eastern Virginia Medical School in Norfolk, Virginia, creates a COVID-19 hospital treatment protocol for the medical school. Called the EVMS protocol, it is based on Dr. Marik’s safe, effective treatment protocol for sepsis — the famous “Marik Cocktail” of intravenous Hydrocortisone, Ascorbic Acid, and Thiamine (HAT). CITRIS-ALI, a large double-blind placebo controlled trial of high dose ascorbic acid (AA) in Acute Respiratory Distress Syndrome (ARDS) found that mortality decreased and ICU length-of-stay were markedly reduced in the treatment group. The reasons for the lack of immediate adoption of this therapy in ARDS can only be explained by the fact that the original primary outcome analysis failed to account for all the early excess deaths in the control group, where no Sequential Organ Failure Assessment (SOFA) score was assign...