Long COVID in 2025: Latest Research, Symptoms, and Treatment Advances
.png)
More than four years following the emergence of COVID-19, a subset of individuals experience persistent, multisystem symptoms extending beyond three months post-infection or post-exposure to mRNA-based COVID-19 vaccines. This condition, historically termed "Long COVID," has recently been redefined by some researchers as "Post-Spike Syndrome" (PSS) or "SPIKEOPATHY," emphasizing the pathogenic role of the SARS-CoV-2 Spike protein derived from both viral infection and mRNA vaccination. This article summarizes the most recent scientific findings and clinical advances to help patients and healthcare providers better understand and manage this complex condition. Latest Research Insights on Long COVID Immune System Markers and Genetic Risk Factors A recent clinical study led by Cardiff Metropolitan University and Cwm Taf Morgannwg University Health Board identified elevated levels of the immune protein Interleukin-6 (IL-6) in people suffering from Long COVID co...