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Long COVID in 2025: Latest Research, Symptoms, and Treatment Advances

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More than four years following the emergence of COVID-19, a subset of individuals experience persistent, multisystem symptoms extending beyond three months post-infection or post-exposure to mRNA-based COVID-19 vaccines.  This condition, historically termed "Long COVID," has recently been redefined by some researchers as "Post-Spike Syndrome" (PSS) or "SPIKEOPATHY," emphasizing the pathogenic role of the SARS-CoV-2 Spike protein derived from both viral infection and mRNA vaccination.  This article summarizes the most recent scientific findings and clinical advances to help patients and healthcare providers better understand and manage this complex condition. Latest Research Insights on Long COVID Immune System Markers and Genetic Risk Factors A recent clinical study led by Cardiff Metropolitan University and Cwm Taf Morgannwg University Health Board identified elevated levels of the immune protein Interleukin-6 (IL-6) in people suffering from Long COVID co...

Resolving Spike Protein Syndrome – Clearing the Spike from Blood and Cells

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BY THOMAS E. LEVY, MD, JD As the acute cases of COVID have continued to decline, the prevalence of the Persistent Spike Protein (PSP) syndrome has continued to increase. The spike protein is that part of the COVID pathogen that attaches to ACE2 receptors throughout the body and permits the entry of the entire virus into the newly infected cell. There appear to be no cells, tissues, or organs in the body that are completely spared from this PSP attack once enough of it has been introduced into the body. The many mechanisms of action involved in the ultimate removal of spike protein. The persistent presence of the spike protein has been shown to be secondary to the inability to completely resolve a bout of COVID (chronic COVID or long-haul COVID) as well as the spike protein exposure from mRNA inoculation(s). And as more time has passed, the PSP syndrome following one or more mRNA shots has emerged as the most common reason for PSP, especially following a booster injection. Not surprisi...

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