Immune Systems Advisor

The McCairn Protocol (Edogawa–McCairn Protocol): Overview and Mechanistic Rationale The McCairn Protocol (also referred to as the Edogawa–McCairn Protocol ) is an experimental, two-phase treatment approach promoted by Kevin McCairn in collaboration with Edogawa Hospital. It is primarily proposed for individuals with Long COVID and post-mRNA vaccine–associated syndromes , targeting hypothesized drivers such as persistent spike protein, amyloid-like fibrin microclots, autoantibodies, chronic inflammation, and associated vascular or neurological dysfunction. Phase 1: Double Filtration Plasmapheresis (DFPP) / Plasma Adsorption (“Cleansing”) Double Filtration Plasmapheresis (DFPP) is a specialized form of therapeutic apheresis currently used in parts of Asia, including Japan, for selected autoimmune, neurological, and metabolic conditions. Procedure Blood is withdrawn, often via a large-bore catheter (e.g., internal jugular access). It is passed through a dual-filtration syste...

Dr. McCullough explained (1) that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. He cited more than 300 papers documenting spike deposits in the heart, brain, and vascular tissue, relating these findings to post‑vaccine myocarditis, strokes, and clotting disorders. A chief diagnostic...

Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough Protocol 2022 Update: Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial ( JAMA 2025 ) Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the prior strains of the virus. Thus, there is a wonderful opportunity to reduce viral replication, in fa...

Do nasal sprays actually work against COVID-19? There has been quite a lot of activities in the COVID nasal spray space.  Two old-school nasal sprays—one antihistamine (azelastine) and one seaweed-derived barrier (iota-carrageenan)—now have randomized human data suggesting they can lower the risk of infection when used regularly during high exposure events (such as air travel, parties, etc). Below, we look at some of the best nasal sprays for COVID-19 and summaries of the rationale and evidence for each category. Do note that some of them are available as an over-the-counter medication but some are still under clinical trial stage. Best Nasal Sprays for COVID-19 There are lots of great nasal sprays out there, and this list is by no means complete. We’ve included nasal sprays with proven anti-COVID-19 ingredient, you can buy over the counter or online. 1. Povidone   Iodine Nasal Spray   and COVID-19 Povidone...

Please enjoy this continuing medical education lecture delivered at 40th Cellular Detoxification Conference sponsored by International College of Integrative Medicine in Indianapolis, Indianana, on September 7, 2024. There are no medicine grand rounds or primary care conferences addressing this topic. It is a white space in medicine where no academic medical center has a fundamental approach to handling about 5-10% of the population suffering from post-acute sequalae after recurrent SARS-CoV-2 infection or COVID-19 infection. Both load the body with pathogenic Spike protein which incites inflammation, oxidative stress, coagulation, and all the downstream effects that result in symptoms. BSD=Base Spike Detoxification Because I have taken the ultimate accountability for McCullough Protocol Base Spike Detoxification (BSD) by publishing and copyrighting it in my own name, I can tell you first hand I get feedback about perceived safety and efficacy on a regular basis from all ov...