Clinical Protocol for the Degradation and Clearance of Persistent SARS-CoV-2 Spike Protein: A Multi-Agent Spike Detoxification Review (2026)
Clinical Therapeutics & Review Papers OneDayMD Clinical Review Team • Published Collaboratively • Updated: June 2026 Abstract The persistence of the SARS-CoV-2 spike protein within human tissue post-acute infection or via repeat genetic vaccination has emerged as a focal point in the pathology of Long COVID (Post-Acute Sequelae of COVID-19) and associated multi-system immune injuries. This review analyzes the clinical rationale behind the "Base Spike Detox" protocol pioneered by Dr. Peter McCullough, MD, MPH. The protocol deploys a triple oral combination of oral nattokinase, bromelain, and nano/liposomal curcumin to accelerate the systemic breakdown and clearance of persistent spike antigens. We evaluate the proteolytic (protein-breaking), fibrinolytic (clot-dissolving), and anti-inflammatory mechanisms of these over-the-counter agents, review preliminary real-world evidence, outlin...