Immune Systems Advisor

More than four years after COVID-19 first appeared, many people still suffer from long-lasting symptoms after getting infected. This ongoing condition was often called 'Long COVID'. It means symptoms stick around for three months or more after the infection or after exposure to certain COVID-19 vaccines that use mRNA technology. In late 2023, some researchers introduced a new name, "SPIKEOPATHY," to explain that a protein called the Spike protein—found in both the virus and mRNA vaccines—plays a big role in causing these long-term problems. Because of this, the term Post-Spike Syndrome (PSS) is suggested as a clearer name for this condition. What is Post-Spike Syndrome? PSS can affect many parts of the body and cause serious, long-lasting health problems. Scientists are learning more about how the Spike protein causes these issues. The tiny particles from mRNA vaccines can travel through the body, not just stay where the shot was given. Both these particles and the Sp...

Dr. McCullough explained (1) that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. He cited more than 300 papers documenting spike deposits in the heart, brain, and vascular tissue, relating these findings to post‑vaccine myocarditis, strokes, and clotting disorders. A chief diagnostic...

Abstract Interest in “spike protein detoxification” has increased following reports of persistent symptoms after COVID-19 infection or vaccination. Protocols promoted by Peter A. McCullough and others typically include nutraceutical combinations such as nattokinase, bromelain, and curcumin. Concurrently, “spike protein testing” using antibody assays has been proposed to guide therapy. This review critically evaluates: The biological plausibility of spike protein persistence The McCullough detox protocol The role and limitations of spike protein testing The current level of clinical evidence Key finding: While hypotheses exist and early observational data suggest possible mechanisms, there is currently no high-quality clinical evidence supporting routine spike protein detoxification or testing in asymptomatic individuals. In the meantime we must be perceptive as patients and open-minded as clinicians to come up with reasonable approaches that can be used to help those sick n...