Immune Systems Advisor

Updates:  COVID-19 Vaccine Labels Updated With Expanded Warnings About Risk of Heart Inflammation (June 2025) COVID-19 Vaccine Myocarditis More Common and More Severe Than SARS-CoV-2 Infection Myocarditis: Landmark Study (2025) Stanford Study Pinpoints Cause of Vaccine-Linked Myocarditis and a Possible Fix (Dec 2025) Damage to the heart is more common than thought after receipt of Moderna’s COVID-19 booster, a  July 2023 study  indicates. One in 35 health care workers at a Swiss hospital had signs of heart injury associated with the vaccine, mRNA-1273, researchers found. “mRNA-1273 booster vaccination-associated elevation of markers of myocardial injury occurred in about one out of 35 persons (2.8%), a greater incidence than estimated in meta-analyses of hospitalized cases with myocarditis (estimated incidence 0.0035%) after the second vaccination,” the researchers wrote in the paper, published by the European Journal of Heart Failure. In a generally healthy population...

Abstract  Unheralded cardiac arrest among previously healthy young people without antecedent illness, months or years after coronavirus disease 2019 (COVID-19) vaccination, highlights the urgent need for risk stratification. The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventricular tachycardia or spontaneous ventricular fibrillation that is commonly precipitated after a surge in catecholamines during exercise or the waking hours of terminal sleep. Small patches of inflammation and/or edema can be missed on cardiac imaging and autopsy, and the heart can appear grossly normal. This paper reviews evidence linking COVID-19 vaccines to cardiac arrest where unfortunately the majority of victims have had no antecedent clinical evaluation. We propose a comprehensive strategy for evaluating cardiovascular risk post-vaccination, incorporating detailed patient history, antibody testing, and cardiac diagnostics in the best attempt to detect abnormaliti...

Backed by 341 references, the new study calls for immediate withdrawal of COVID-19 mRNA products from the market due to cardiotoxicity concerns. The McCullough Foundation study authored by M. Nathaniel Mead, Jessica Rose, William Makis, Kirk Milhoan, Nicolas Hulscher (myself), and Peter A. McCullough, was just published in the International Journal of Cardiovascular Research & Innovation: Myocarditis after SARS-CoV-2 infection and COVID-19 vaccination: Epidemiology, outcomes, and new perspectives . ABSTRACT Myocarditis, typically manifesting as myopericarditis, is among the serious cardiac consequences observed over the course of the COVID-19 pandemic. We performed a comprehensive, evidence-based literature synthesis of findings from clinical trial data reanalyses, post-marketing surveillance, large observational studies, and other diverse research sources that help shed light on the phenomenon of myocarditis post SARS-CoV-2 infection versus COVID-19 vaccine-induced myocarditis. Ou...