Immune Systems Advisor

By Editorial Team | Originally published July 2022 | Fully revised and evidence-updated September 2026 | Reviewed against the 2026 ivermectin randomized-trial meta-analysis and current FDA/WHO guidance Quick Answer I-PREVENT is a pre- and post-exposure prevention protocol published by the Independent Medical Alliance (formerly the FLCCC), pairing common-sense measures with supplements — vitamin D, C, zinc, melatonin, elderberry, quercetin — and, more controversially, ivermectin and hydroxychloroquine. Vitamin D correction has genuine randomized-trial support for reducing respiratory infections, particularly in people who are deficient. Ivermectin does not : the largest and most recent synthesis of evidence, a 2026 meta-analysis of 40 randomized trials in over 23,000 people, found no statistically significant reduction in infection risk from prophylaxis and no meaningful treatment benefit — a conclusion shared by the FDA, WHO, and IDSA. Ivermectin and hydroxychlor...

As rates of infection with influenza and RSV rose in fall/winter 2022, FLCCC adapted the I-PREVENT protocol to include prevention against these viruses. The interventions recommended are likely to reduce the risk and severity of infection with COVID-19, influenza, and RSV infections as well as the common cold. It should be noted that the medications included in the I-PREVENT protocol are inexpensive, safe, and widely available. This protocol includes a section for pre-exposure (long-term) as well as a post-exposure (acute, short-term). ( Independent Medical Alliance ) About this Protocol The information in this document is FLCCC recommended approach to COVID-19 based on the best (and most recent) literature. It is provided as guidance to healthcare providers worldwide on the early treatment of COVID-19. Patients should always consult with their provider before starting any medical treatment. New medications may be added and/or changes made to doses of existing medications a...

A Guide to Diagnosing and Managing Influenza and Respiratory Syncytial Virus (RSV) Infections in Adults In adult patients, COVID-19 (Omicron variant), influenza, and RSV present with similar symptoms and can, therefore, be difficult to distinguish. This guide aims to help diagnose and treat Influenza and Respiratory Syncytial Virus (RSV). Update: Oseltamivir Treatment vs Supportive Care for Seasonal Influenza Requiring Hospitalization (JAMA 2025) For advice on how to protect yourself against infection, see  I-PREVENT: COVID, Flu and RSV Protection Protocol . For treatment of COVID-19, see  I-CARE: Early COVID Treatment Protocol . For treatment of Post Vaccine Complications, see I-RECOVER: Post Vaccine Treatment . Update: Added Minocycline (Jan 2023 update) Note that there are two I-Care Protocols; the I-Care Covid protocol to treat Covid and this protocol, I-Care Flu protocol.  About this Protocol The information in this document is our recommended approach to COVID-19 ...