10 Best Supplements to Remove Spike Protein for 2024

The spike protein is naturally found in SARS-CoV-2, no matter the variant. In its native form in SARS-CoV-2, the spike protein is responsible for the pathologies of the viral infection.

In its wild form it’s known to open the blood-brain barrier, cause cell damage (cytotoxicity) and, as Dr. Robert Malone, the inventor of the mRNA and DNA vaccine core platform technology, said in a commentary on News Voice, “is active in manipulating the biology of the cells that coat the inside of your blood vessels — vascular endothelial cells, in part through its interaction with ACE2, which controls contraction in the blood vessels, blood pressure and other things.”

It’s also been revealed that the spike protein on its own is enough to cause inflammation and damage to the vascular system, even independent of a virus. (R

In this Article:
  • Natural Treatments
    1. Nattokinase, Bromelain and Curcumin
    2. Melatonin
    3. Probiotics
    4. Vitamin D3 and K2
    5. Vitamin C
    6. Omega-3 fatty acids
    7. N-Acetyl-L-Cysteine (NAC)
    8. Quercetin and Green Tea Extract
    9. Resveratrol
    10. Zinc
  • FLCCC I-Recover Protocol

Best Natural Treatments to Remove Spike Protein

We will cover some of the best natural supplements below, that may have a role in the treatment of this disorder. Please take note that the purpose of this article is to educate and to assist you in doing your own research. Before you take any supplements, it's best you find a doctor to discuss with.

1. Nattokinase, Bromelain and Curcumin

If you’ve had COVID-19, especially if it was a severe case, be aware that blood clots and heart problems, including heart attack, can occur for 90 days or more. It’s believed that remnants of the virus remain in the nervous system, the lungs, the heart and other organs.

If the symptoms include major shortness of breath, cough with blood in it or pain on one side when you take a deep breath, it could be due to a late pulmonary embolism or a blood clot going to the lungs. 

According to a November 2023 study, published in Cureus:

We propose a base spike detoxification protocol, composed of oral nattokinase, bromelain, and curcumin. This approach holds immense promise as a base of clinical care, upon which additional therapeutic agents are applied with the goal of aiding in the resolution of post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination.

Based on the emerging scientific literature and clinical observation, that three OTC products are essential as a triple base combination:
  1. Nattokinase 2000 FU (100 mg) twice a day
  2. Bromelain 500 mg once a day
  3. Nano/Liposomal Curcumin 500 mg twice a day
Additional products can be added, including NAC, IVM (Ivermectin), HCQ (Hydroxychloroquine), fluvoxamine, low-dose naltrexone, and blood thinners, depending on the clinical evaluation and the syndrome. The therapeutic objective is to start treatment and allow the body to clear Spike and its fragments with the natural reticuloendothelial system. I believe this triple combination is the best approach.

Patients can get a big head start if they self-initiate Base Spike Detox as they get organized for appointments. I have found three months is a minimum duration, and some require more than a year. Don’t expect instant results, be patient. I have a major manuscript under review for publication that summarizes the clinical rationale and evidence supporting Base Spike Detox.

Important safety warnings include bleeding for those on blood thinners or who have bleeding disorders (e.g., hemophilia), soy allergy, allergies to any component of the combination, and gastrointestinal intolerance. Women of childbearing potential without contraception, pregnant, breastfeeding, and children should not take this combination unless directed by a doctor.

Read More: How to Detox Spike Protein from Body

2. Melatonin

Melatonin has anti-inflammatory and antioxidant properties and is a powerful regulator of mitochondrial function [R]. It also supports the gut lining, which promotes healthy immune function.

Supplementing with 1 - 2 mg of melatonin at bedtime might benefit those whose sleep–wake cycles have become dys­regulated with long COVID.

Melatonin is also one of the optional adjunctive therapies of the FLCCC i-Recover protocol for long haul syndrome. FLCCC has launched a new version of i-Recover protocol for post-vaccine syndrome which include melatonin as one of the important first line treatments.

3. Probiotics

COVID can wreak havoc on the gut microbiome, but research on specific probiotic strains that can best restore balance following the syndrome’s particular damage is in its infancy. Leo Galland, MD, a functional-medicine internist in New York City, is looking into soil-derived bacteria of the genus Bacillus because it may have natural antibiotic properties, though there’s not yet enough data to make specific recommendations.

One Swedish study demonstrated that taking probiotics for 14 days could help alleviate some of the symptoms of long COVID, namely muscle soreness and brain fog. We also recommend optimizing your gut microbiome by avoiding processed vegetable oils, processed foods and conventionally raised meats in animal products.

Probiotics is one of the first line therapies of the FLCCC i-Recover protocol for post-vaccine syndrome.

Eating fermented foods, such as sauerkraut, yogurt, kefir, and kimchi, can help fortify and support the gut’s microbiome. And in the event of ongoing gut disturbances, working with a functional-medicine provider to design a well-rounded prebiotic and probiotic protocol can help bring the microbiome back into balance.

As reported in this short news clip, research evidence shows that probiotics may help reduce long-haul symptoms after COVID-19. Some people experience symptoms for weeks or months after a COVID-19 infection has resolved. When these symptoms persist for four weeks or more, they are known as long COVID, long-haul COVID, chronic COVID or long-haul syndrome.

4. Vitamin D3 and K2

Vitamin D3 is essential for supporting healthy immune system function. It works hand in hand with your body to modulate both innate and adaptive immune responses which regulate everything from reactivity to antigens and pathogens.

Maintaining good vitamin D status should be a priority even as a preventive measure, and may help restrain inflammation from elevating during COVID in the first place.

The majority of those with post-COVID-19 syndrome continue to have low levels of vitamin D in their bodies.

Vitamin D is also one of the recommended treatments in FLCCC's i-Recover protocol for post-vaccine syndrome.

According to FLCCC's i-Recover protocol for Long COVID, the majority of those with post-COVID-19 syndrome continue to have hypovitaminosis D (low vitamin D level). See tables 1 or 2 for vitamin D supplementation below.

Substance: Vitamin D3
Natural Source(s): Fatty fish, fish liver oils, milk, eggs
Where to Get: Supplement: health food stores, pharmacies, dietary supplement stores 
Recommended Dose: 5000 IU daily  (Consume with K2) (Buy Online)

Substance: Vitamin K2
Natural Source(s): green leafy vegetables
Where to Get: Supplement: health food stores, pharmacies, dietary supplement stores (Buy Online)
Recommended Dose: 90-120mcg daily  (90 for women, 120 for men)

5. Vitamin C

Vitamin C has important anti-inflammatory, antioxidant, and immune-enhancing properties, including increased synthesis of type I interferons. [R] Avoid in patients with a history of kidney stones. Oral Vitamin C also helps promote growth of protective bacterial populations in the microbiome. 

Vitamin C inhibits histamine. Healthcare professionals are administering vitamin C intravenously to deliver it directly into their patient’s bloodstream to be immediately available. Liposomal vitamin C is the next best option. It’s the most bioavailable form of vitamin C on the market today. The liposomal form can survive the digestive process to be up to 135% better than traditional oral vitamin C.

Long-COVID patients can supplement with liposomal vitamin C 500 mg twice a day. 

The Italian nationwide multi-centre LINCOLN study (L-Arginine and Vitamin C improves Long-COVID) results, published in Pharmacological Research in September 2022, was the first to show the beneficial effects of the combination of L-Arginine and Vitamin C in Long-COVID.

L-Arginine and Vitamin C in Long-COVID


6. Omega-3 fatty acids

Vascepa, Lovaza or DHA/EPA 4 g day. Omega-3 fatty acids play an important role in the resolution of inflammation by inducing resolvin production. [RefRef

Evidence: Two peer-reviewed randomized, controlled trials suggest that omega-3 fatty acids help hasten recovery from COVID, and when given to ICU patients may make them six times more likely to survive.

Omega-3 is also part of the first line treatments of the FLCCC i-Recover protocol (below).

7. Quercetin and Green Tea

Quercetin has broad spectrum anti-inflammatory properties. These natural flavonoids inhibit mast cells and have been demonstrated to reduce neuro-inflammation. 

Flavonoids have broad spectrum anti-inflammatory properties, inhibit mast cells, [R] and have been demonstrated to reduce neuroinflammation. [R] Due to the possible drug interaction between quercetin and ivermectin (see below) these drugs should not be taken simultaneously (i.e., should be staggered morning and night). 

Quercetin is found in dill, broccoli, onions, capers, apples, and berries. 

Quercetin appears to bind to the spike protein of the coronavirus, inhibit inflammatory pathways, and block replication of infected cells. It is also antiviral and completely safe. In addition to getting sources of quercetin from diet, long-COVID patients can supplement with 250 - 500 mg a day. 

Other phytonutrients such as EGCG (epigallocatechin gallate, a polyphenol found in green tea) and curcumin (found in turmeric) can also decrease inflammation and rebalance the immune system. 

8. N-Acetyl-L-Cysteine (NAC)

NAC is an amino acid that the body uses to create glutathione, the body’s master detoxifier. Glutathione is your master detoxifier and the most powerful free radical scavenger produced by your body.

Eating plenty of cruciferous vegetables (such as kale, broccoli, and cabbage), as well as avocado, okra, spinach, and alliums, can help bolster levels of gluta­thione, as can supplementing with NAC.

2017 paper found NAC has potent thrombolytic effects, meaning it breaks down blood clots once they've formed.

Importantly, NAC may also protect against other problems associated with COVID-19, including the hypercoagulation that can result in stroke and/or blood clots that impair the ability to exchange oxygen in the lungs.

Many COVID-19 patients experience serious blood clots, and NAC counteracts hypercoagulation, as it has both anticoagulant and platelet-inhibiting properties.

Aaron Hartman, MD, founder of the Richmond Integrative and Functional Medicine clinic in Richmond, Va., describes one patient, a 26-year-old woman, whose symptoms — persistent low oxygen and shortness of breath — following a bout of COVID resolved after treatment that included NAC as well as omega-3 fish oil.

“NAC is one of the more important nutrients for people who get shortness of breath with COVID, because of its ability to break down those really, really small blood clots called micro-emboli,” explains Hartman.

9. Resveratrol

Resveratrol is a polyphenol with anti­oxidant and anti-inflammatory effects that’s found in red grapes, red wine, ­peanuts, and some berries. It’s also available as a supplement.

Leo Galland, MD, a functional-medicine internist in New York City, has found it to be particularly helpful in restoring his COVID patients to health. “Resveratrol has a number of beneficial effects on coronavirus infection,” he notes. “It supports ACE-2 function, it inhibits the growth of the deadly MERS coronavirus through multiple mechanisms, and it diminishes the kind of inflammation associated with coronavirus infection.”

Galland treated a physician in her 60s who’d been sick with COVID for six weeks, continuing to run daily fevers with brain fog and fatigue. He prescribed a combination of herbs and supplements, including resveratrol, and her symptoms resolved within a couple of weeks.

He recommends long-COVID patients supplement with 200 mg of resveratrol twice a day.

Natural Source(s): Peanuts, grapes, red wine, blueberries, cocoa
Where to Get: Supplement: health food stores, pharmacies, dietary supplement stores, online
Recommended Dose: Up to 1500 mg daily for up to 3 months

10. Zinc

Zinc is essential for healthy immune function. A 2020 review published in the International Journal of Infectious Diseases has found that zinc deficiency can increase the risk of poor outcomes in viral infections, including COVID-19.

Foods that are rich in zinc include meat, poultry, shellfish, eggs, dairy, seeds, nuts, legumes, sweet potatoes, quinoa, and green leafy vegetables. 

FLCCC I-Recover Protocol

The I-Recover protocol (Long COVID) has been updated and below is their latest version (Oct 3, 2023). 

Treatment must be individualized according to each patient’s presenting symptoms and disease syndromes. It is likely that not all patients will respond equally to the same intervention; a particular intervention may be life-saving for one patient and totally ineffective for another. Early treatment is essential; it is likely that the response to treatment will be attenuated when treatment is delayed. 

Patients with post-vaccine syndrome should do whatever they can to prevent themselves from getting COVID-19. This may include a preventative protocol (see I-PREVENT) or early treatment in the event you do contract the virus or suspect infection (see I-CARE). COVID-19 will likely exacerbate the symptoms of vaccine injury.

Once a patient has shown improvement, the various interventions should be reduced or stopped one at a time. A less intensive maintenance approach is then suggested.

The core problem in post-vaccine syndrome is long-lasting “immune dysregulation.” The most important treatment goal is to help the body restore a healthy immune system — in other words, to let the body heal itself. Our recommended treatment strategy involves two major approaches:
  • Promote autophagy to help rid the cells of the spike protein
  • Use interventions that limit the toxicity/pathogenicity of the spike protein
FLCCC recommend the use of immune-modulating agents and interventions to dampen and normalize the immune system rather than the use of immunosuppressant drugs, which may make the condition worse.

Note that there are significant overlaps between the symptoms and features of long COVID/long-hauler syndrome and post-vaccine syndrome. However, a number of clinical features appear to be characteristic of post-vaccine syndrome; most notably, severe neurological symptoms appear to be more common following vaccination. To complicate matters further, patients with long COVID are often also vaccinated, making the issue of definition more difficult. 

Diagnostic Tests for Long COVID

The following basic tests are recommended — tests such as cytokines and chemokines, autoantibodies, and toxicological studies are expensive, have very little clinical relevance, and only complicate the management of long COVID patients.

  • CBC with lymphocyte count and CD8+ count
  • Chemistry with liver function tests
  • CRP (inflammation)
  • Ferritin (macrophage activation)
  • D-dimer
  • Early morning cortisol
  • Thyroid function tests
  • HbA1C—long COVID patients are at an increased risk of developing diabetes
  • Autoantibodies: antiphospholipid antibody and ANA
  • In patients with allergic features or those who experienced an acute reaction to the vaccine, the following tests may be helpful: eosinophil count; IgE levels, RAST testing and/or skin testing. Serum tryptase, serum histamine and/or 24-h urine N- methylhistamine should be considered in MCAS.
  • Reactivated viruses: Antibodies/PCR against EBV Herpes I/II and CMV
  • Vitamin D level

Specific Phenotypic tests

  • CXR / chest CT with contrast
  • Brain MRI
  • ECHO


(Not symptom specific; listed in order of importance; see full treatment strategy for detailed dosing information)

  • Intermittent daily fasting or periodic daily fasts: Fasting stimulates the clearing of damaged mitochondria (mitophagy), misfolded and foreign proteins, and damaged cells (autophagy). Autophagy likely removes spike protein and misfolded proteins induced by the spike protein. Autophagy may therefore play a critical role in reversing the “spikopathy” induced by COVID infection. Indeed, activation of autophagy may be the only mechanism to remove intracellular spike protein.
  • Ivermectin: It is likely that ivermectin and intermittent fasting act synergistically to rid the body of the spike protein. Ivermectin binds to the spike protein, aiding in the elimination by the host. Ivermectin also has potent anti-inflammatory properties.
  • Moderating physical activity: Patients with long COVID frequently suffer from severe post-exertional fatigue and/or worsening of symptoms with exercise. We recommend moderating activity to tolerable levels that do not worsen symptoms, keeping the patient’s heart rate under 110 BPM. Furthermore, patients need to identify the activity level beyond which their symptoms worsen, and then aim to stay below that level of activity. Stretching and low-level resistance exercises are preferred over aerobic exercises.
  • Low-dose naltrexone: This medication has been demonstrated to have anti-inflammatory, analgesic, and neuromodulating properties.
  • Nattokinase: This highly effective fibrinolytic and antiplatelet agent targets the abnormal clotting that can occur from spike protein-related disease. (McCullough 2023)
  • Melatonin: A powerful regulator of mitochondrial function, melatonin has anti-inflammatory and antioxidant properties. Should be taken prior to bedtime.
  • Magnesium: At least 11 different types of magnesium are available, with varying bioavailability.
  • Low-dose Methylene Blue: This is a therapeutic option in patients with brain fog and other neurological symptoms. The optimal dose is highly individualized and each patient needs to find the right dose for them.
  • Sunlight and Photobiomodulation (PBM): Sunlight has great therapeutic powers. We suggest patients expose themselves to about 30 minutes of midday sunshine whenever possible (at least 3 times a week). A brisk midday walk is a viable alternative, as is red and NIR radiation emitted from LED panels.
  • Vitamin D and K2
  • Resveratrol or a combination flavonoid
  • Probiotics/prebiotics: Patients with long COVID classically have a severe dysbiosis with loss of Bifidobacterium.


(Listed in order of importance; see full treatment strategy for detailed dosing information)

  • Omega-3 fatty acids: We suggest a combination of EPA/DHA.
  • N-acetyl cysteine (NAC): NAC has a broad range of antioxidant, anti-inflammatory, and immune-modulating mechanisms.
  • Cardio MiracleTM and L-arginine/L-citrulline supplements: These supplements increase nitric oxide (NO) production.
  • Nigella sativa: Taken as a supplement, in oil form, or as seeds, nigella sativa (also known as Black Seed or Kalonji) has antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, and immunomodulatory properties.
  • Sildenafil with or without L-arginine-L-Citrulline: This may be helpful for brain fog as well as microvascular disease with clotting and poor perfusion.
  • Bromelain: In vitro studies have demonstrated that bromelain cleaves the spike protein. This effect may be enhanced by NAC.
  • Vitamin C: This vitamin is essential to human health and has important anti-inflammatory, antioxidant, and immune-enhancing properties. Oral Vitamin C also helps promote the growth of protective bacterial populations in the microbiome.
  • Spermidine: Spermidine is a naturally occurring polyamine that, like resveratrol, has anti-inflammatory and antioxidant properties.
  • Non-invasive brain stimulation (NIBS): Using transcranial direct current stimulation or transcranial magnetic stimulation, NIBS has been demonstrated to improve cognitive function in patients with long COVID as well as other neurological diseases.
  • Intravenous Vitamin C
  • Behavioral modification, relaxation therapy, mindfulness therapy


  • Hyperbaric oxygen therapy
  • Low Magnitude Mechanical Stimulation
  • “Mitochondrial energy optimizer”
  • Hydroxychloroquine
  • Low dose corticosteroid

A note about anesthesia and surgery:

Patients should notify their anesthesia team if using the following medications and/or nutraceuticals, as they can increase the risk of Serotonin syndrome with opioid administration:

  • Methylene blue
  • Curcumin
  • Nigella Sativa
  • Selective Serotonin Reuptake Inhibitors (SSRIs)

About Ivermectin

Ivermectin is a well-known, FDA-approved drug that has been used successfully around the world for more than four decades. One of the safest drugs known, it is on the WHO’s list of essential medicines, has been given over 3.7 billion times, and won the Nobel Prize for its global and historic impacts in eradicating endemic parasitic infections in many parts of the world.

Review the totality of supporting evidence for ivermectin: https://c19ivm.org.

Long COVID vs Long Vax

Many of the symptoms of long COVID are common to COVID-19 vaccine injury (also known as long vax); indeed, both disorders are considered manifestations of “spike protein-related disease” with a significant overlap in symptoms, pathogenesis, and treatment. (R)

The major difference between long COVID and long vax is unresolved organizing pneumonia with persistent respiratory symptoms. Clinicians have also noted that long-vax patients tend to have more severe illness due to a higher incidence and severity of neuropathic symptoms and dysautonomia.

Long COVID and long vax are heterogeneous syndromes, meaning their symptoms and clinical features vary widely in presentation, severity, and underlying causes or contributing factors. Both are characterized by prolonged malaise, headaches, generalized fatigue, sleep difficulties, hair loss, smell disorder, decreased appetite, painful joints, dyspnea, chest pain, and cognitive dysfunction. Patients may suffer prolonged neuropsychological symptoms, including multiple domains of cognition.

The symptom set of long COVID is, in the majority of cases, very similar to chronic inflammatory response syndrome (CIRS)/myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). An important differentiating factor from CIRS is the observation that long COVID continues to improve on its own, albeit slowly in most cases. Another important observation is that long COVID includes more young people compared to severe COVID, which affects older people or persons with comorbidities. Furthermore, the similarity between mast cell activation syndrome (MCAS) and long COVID has been observed, and many consider long COVID to be a variant of MCAS.

Treating Organizing Pneumonia

As noted previously, the major difference between long COVID and long vax is unresolved organizing pneumonia with persistent respiratory symptoms. Therefore, in patients with ongoing respiratory symptoms, chest imaging is suggested (preferably a chest CT scan). (R)

Those with unresolved pulmonary inflammation (organizing pneumonia with ground glass opacification) should be treated with a course of corticosteroids. Low-dose prednisolone/methylprednisolone (10 mg/day) for six weeks is suggested. However, the patient’s symptoms and CRP should be followed closely, as a dose escalation may be required in those who respond poorly.

An unknown number of patients who have recovered from COVID-19 organizing pneumonia will develop pulmonary fibrosis with associated limitation of activity. Pulmonary function testing demonstrates a restrictive type pattern with decreased residual volume and DLCO. These patients should be referred to a pulmonologist with expertise in pulmonary fibrosis. Anti-fibrotic therapy may have a role in these patients, however additional data is required before this therapy can be more generally recommended. The serotonin receptor blocker cyproheptadine may reduce the risk of pulmonary fibrosis.


Z-Dtox Supplement

z-dtox zelenko

Dr. Vladimir Zelenko’s groundbreaking work on the immune system has led to this exciting breakthrough.

Your immune system can be weakened by over 300 different primary immunodeficiency disorders, poor diet, lack of sleep, and adverse reactions to various vaccines.

That’s where Z-DTOX comes in! Z-Dtox is Dr. Zelenko’s proprietary combination of ECGC, NAC, Zinc, Vitamin C, and Vitamin D.

  • Epigallocatechin gallate (EGCG) is an extract of green tea and is a powerful zinc Ionophore (zinc delivery system).
  • N-acetyl cysteine (NAC) is a supplement form of cysteine. It may prevent blood clots and is an antioxidant.
  • Zinc is critical for immune cell development. Dozens of different enzymes in the body rely on zinc.
  • Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters.
  • Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.
Z-Dtox is more powerful than Z-Stack. It has EGCG instead of Quercetin, NAC, and higher dose Zinc. It is more appropriate for higher risk patients. For example, those people that have a dysfunctional immune system, risk of blood clots, older people and those with chronic medical conditions.

Z-Dtox also has 60 servings per container instead of 30 servings per container for Z-Stack.

Where to buy Z-Dtox: Z-Dtox is available on Dr Zelenko's website. Here is the link: Z Dtox Supplement 

Note: To get 5% OFF, please use this coupon code: drfrancis


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