Xylitol Nasal Spray Prevents SARS-CoV-2 Infection: Study

The sophisticated American consumer has grown accustomed to the gold standard for drug and health products—the prospective randomized, double-blind, placebo-controlled trial (RCT). Operation Warp Speed (OWS) was supposed to be a churning mill of large RCTs to help the nation understand what conclusively is effective in the prevention and treatment of COVID-19.

Unfortunately, after three years, OWS has delivered failed products (remdesivir, baricitinib, molnupiravir, COVID-19 vaccines) and small inconclusive trials of products that doctors have found effective in practice, including off-target generic antivirals and anticoagulants. Operation Warp Speed didn’t test simple, affordable, available prevention strategies. Fortunately, such RCTs were done outside of the United States and have brought us important findings.

Balmforth, et al., conducted a prospective double-blind, placebo-controlled trial of a xylitol-based nasal spray in the prevention of SARS-CoV-2 infection in exposed healthcare workers in two hospitals in Uttar Pradesh, India. Xylitol is known to have anti-infective and anti-inflammatory properties and is used in XLEAR nasal spray and anti-infective chewing gum to prevent dental caries.

Damian Balmforth, a cardiac surgeon at St. Bartholomew’s Hospital in London, and a team of researchers found that SARS-CoV-2 infection confirmed by serology was 71 percent lower with xylitol compared to placebo [36 cases (13.1 percent) vs. 97 cases (34.5 percent); odds ratio [OR] 0.29 (95 percent CI; 0.18–0.45), p < 0.0001]. Fewer clinical symptoms were also seen in the test group [57 cases (17.6 percent) vs. 112 cases (34.6 percent); OR 0.40, (95 percent CI; 0.27–0.59), p < 0.0001].

No harmful effects were associated with xylitol. A smaller study of xylitol nasal spray in mild COVID-19 cases demonstrated that persistent loss of smell may be eliminated with xylitol nasal spray during the acute congestion phase. Epoch Times Photo
Balmforth D, Swales JA, Silpa L, Dunton A, Davies KE, Davies SG, Kamath A, Gupta J, Gupta S, Masood MA, McKnight Á, Rees D, Russell AJ, Jaggi M, Uppal R. Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-center, double-blind, placebo-controlled, randomized trial. J Clin Virol. 2022 Oct;155:105248. doi: 10.1016/j.jcv.2022.105248. Epub 2022 Jul 25. PMID: 35952426; PMCID: PMC9313533.

I’ve been impressed with the RCTs of topical nasal sprays and gargles in COVID-19 far more than those with oral or intravenous drugs. Xylitol available as XLEAR in U.S. pharmacies is one of several choices for local nasopharyngeal protection and treatment of COVID-19.

Reposted from Peter A. McCullough’s Substack

References:

Balmforth D, Swales JA, Silpa L, Dunton A, Davies KE, Davies SG, Kamath A, Gupta J, Gupta S, Masood MA, McKnight Á, Rees D, Russell AJ, Jaggi M, Uppal R. Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-center, double-blind, placebo-controlled, randomized trial. J Clin Virol. 2022 Oct;155:105248. doi: 10.1016/j.jcv.2022.105248. Epub 2022 Jul 25. PMID: 35952426; PMCID: PMC9313533.

Soler E, de Mendoza A, Cuello VI, Silva-Vetri MG, Núñez ZH, Ortega RG, Rizvi SA, Sanchez-Gonzalez M, Ferrer G. Intranasal Xylitol for the Treatment of COVID-19 in the Outpatient Setting: A Pilot Study. Cureus. 2022 Jul 23;14(7):e27182. doi: 10.7759/cureus.27182. PMID: 36039203; PMCID: PMC9395150.

Xlear Xylitol nasal spray where to buyXylitol is available as XLEAR in US pharmacies and on Amazon.

Editor's Note: 

Xlear isn’t the only nasal spray that is showing promise in providing protection against COVID-19. For more options, check out "Best Nasal Sprays for COVID".

Best Comments

We've curated one of the best comments on this article from Epochtimes.

I use Xlear. It’s available online. It’s natural and made here in the US. I have been around my grandkids when they were sick, my daughter a few weeks ago with a bad case of Covid and unmasked mostly from day one of the “pandemic”. Xlear has worked! I tell everyone but most of my vaxed and boosted friends don’t believe a word I say. I look at them and say, “who is sick and who hasn’t been”? There you have it!
- butlerstwo

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