Dr Peter McCullough: Povidone Iodine, Oral and Nasal Hygiene (2024)

Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals.

McCullough Protocol 2022
McCullough Protocol 2022

Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the prior strains of the virus. Thus, there is a wonderful opportunity to reduce viral replication, in fact, kill viruses with agents directly applied in the nasal cavity and the back of the throat. This article is not meant to undermine official guides but to provide additional under-rated evidence for you to decide.

Update (September 2023): How to Detox Spike Protein from Body

Use of directly applied therapy is far more effective than swallowing pills or capsules or receiving an intravenous infusion. The nasal mucosa is a barrier for entry and if functioning well, allows little penetration of virions into systemic circulation where for example a monoclonal antibody could work. Thus, the McCullough Protocol© starting in 2021, featured the upfront use of nasal washes and oral gargles using viricidal agents (R).

Many have asked which solutions, mixtures, and frequencies should be used?

One should be reassured that is far more important to use some form of nasal and oral topical therapy as opposed to letting the infection take its course and ultimately invade the lungs and the internal organs.

For purposes of this stack, we acknowledge that many can be effective including: 
  • povidone-iodine,
  • hydrogen peroxide,
  • colloidal silver,
  • xylitol,
and for the throat many mouthwashes including
  • Scope and
  • Listerine.
Principles are:

1) nasal solutions should be comfortable and not sting with sufficient dilution,

2) sniffed far back into the sinuses and then spit out through the mouth (often causes coughing or mild choking), done at least twice per nostril per session,

3) oral gargles should be for 30 seconds and then spit out. For detailed descriptions of products and solutions please visit one of several websites to get this practical information. (R)

Oropharyngeal viricidal therapy has been demonstrated in supportive studies and randomized trials to:

1) prevent infection after suspected exposure (twice daily),

2) reduce the period of infectivity when ill, and

3) attenuate the progression of disease and reduce the need for oxygenation and hospitalization (six times daily).

Povidone Iodine

10% Povidone Iodine is available OTC (Over the Counter) without a prescription at any drug store for a few dollars. 

Note: This 10% Povidone Iodine must be diluted by one tenth, to 1% strength before use as a mouth wash, otherwise it is too strong and irritating. Dilute by adding 2 tablespoons (30 ml) of the 10% Povidone Iodine into a full glass of water (250-300 ml). This will make the product diluted enough to use as a mouth rinse, or gargle, (approximately 1.0 %).

2 tablespoons = 30ml povidone iodine
1 glass water = 300 ml

Dr. McCullough recommends routine use of this mouthwash on a daily basis, and especially after contact with large indoor groups.

Dr Peter Breggin Interview with Dr Peter McCullough on Brighteon discussing COVID, vaccines, early treatment, prevention with Povidone Iodine mouth wash etc:


Povidone iodine (PVP-I) is an antiseptic that has been used for over 150 years. The antiseptic has immediate virucidal effects against COVID-19 virus. Do we have any evidence that povidone iodine is effective against COVID-19? 

It's important to note that the scientific community relies on evidence-based research to inform medical recommendations and guidelines. If you come across information about a treatment or approach that is not widely accepted or that lacks strong scientific evidence, it's a good idea to do your own research and consult with a healthcare professional before making any decisions.

There are 20 published studies supporting povidone-iodine for COVID-19. You can check out the list at c19pvpi.com (constantly updated).

Povidone-iodine is ranked no. 3 in this COVID-19 early treatment mortality drug league table below.

In a December 4th, 2021 interview with Rebel News, Peter McCullough MD discusses what is known about the Omicron variant, and the use of Povidone Iodine Mouthwash, Povidone Iodine Nasal Antiseptic Wash and Gargle for prevention of Covid-19. Dr. McCullough cites the Choudhury study in which 606 COVID infected patients were randomized to 1% povidone iodine, or saline placebo mouthwash and gargle. Patients were followed with PCR testing for viral load. 

Dr. Iqbal Mahmud Choudhury conducted a protocol in Bangladesh that used a povidone-iodine rinse in the nose, mouth, and eyes to kill the virus. Dr. Choudhury writes:

The group of patients used 1% PVP-I [One per cent Povidone Iodine Solution] have shown tremendously reduced mortality, morbidity and hospital as well as financial burden in this covid situation.

A study by Avinash Bidra found complete inactivation of the virus after 15 seconds of gargling with a 1% Povidone Iodine Solution. According to the authors, Povidone Iodine (1%) solution is “rapidly virucidal” at all dilutions tested.

A reader (Drew458) commented on Naked Capitalism:
My favorite paper is this one from some ENTs in Bangladesh, who diluted common 10% PVP to 0.6% and made it up by the gallon in soda bottles, poured it into plastic sprayers and gave it to hundreds of their patients as a nasal and throat spray. Great pictures. It worked. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026810/

Is it Safe to use Iodine in a nasal rinse?

Povidone-iodine can safely be used in the nose at concentrations up to 1.25% and in the mouth at concentrations up to 2.5% for up to 5 months. Povidone-iodine rapidly inactivates coronaviruses, including SARS and MERS, when applied for as little as 15 seconds.

Povidone Iodine vs Iodine

Despite having similar sounding names, iodine and povidone-iodine are two different compounds and a distinct difference can be noted between these two compounds based on their composition and uses.

Iodine is a pure element, and it contains 100% iodine in its composition. It is found in solid form, grayish black small crystals with a metallic luster. Iodine can be obtained in all three forms; solid, liquid and gas. Liquid iodine is a dark purple colored solution, and iodine gas (I2) is a purple colored gas. 

Povidone-iodine is a complex of iodine and povidone. It has from 9%-12% of iodine on the dry basis. (source)

Pregnancy Warning:

From Betadine Drug Facts - If pregnant, ask a health professional before use.
Editor's Note - Use should be limited for a short period i.e. no more than 5 days according to FLCCC I-MASK+ protocol. Caution is recommended as the therapeutic benefit must be balanced against the possible effects of the absorption of iodine on thyroid development and function.

Do Not Use Iodine-Based Skin Disinfectant for Gargling

Importantly, Neal Naito (M.D., M.P.H., a former director of public health for the U.S. Navy) stresses that povidone-iodine solutions sold as skin disinfectants are NOT suitable for gargling as they contain potentially harmful ingredients that should not be ingested.

“It’s critical that people not gargle with skin disinfectant solutions, including those that contain povidone-iodine,” he says. So, when using povidone-iodine for gargling, be sure to look for solutions such as Betadine formulated specifically as a sore throat gargle, not products intended for cuts and wound care. (source)

Early Treatment Protocols

Early treatment protocols with demonstrated effectiveness include:

Online Shopping Guide:


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  1. Can children older than 2 years old use this solution?

  2. Can children older than 2 years old use this solution?

  3. Wouldn't using nascent iodine be just as good or better?

  4. Thankyou so much for this article. My question is what do you think about diluting the 10% Providing with Colloidal silver 10ppm distilled water solution? Double whammy? Thankyou!

  5. I have a friend of mine who is starting to experience breathing issues... went to ER today... they just gave her cough pills and an inhaler. I don't know what else to do... I'm in California.

  6. I have a friend in her early 30's, obese and it seems that things are getting worse... she's gone to ER today because of wheezing and trouble breathing. They sent her home with inhaler and cough pills. What should she do about this? This has been over 3 weeks now.... she says she feels terrible. But I want to help her with something from McCollough therapeautics but not sure what to tell her to take.. I think we're late for Pov iodine, NAC, and Zinc Quercetin, or D. WHAT CAN I TELL HER?
    Here in California, people are just dying without any hope...

    1. Go to frontline docs website and call one of them. She can do a phone consultation with them and they can prescribe the necessary protocol

  7. Does 10% OTC iodoine have scrubbing agents or fragrances in it?

  8. How long does the diluted solution of Povodone Iodine last on the shelf once mixed?

  9. can I use the povidone-iodine protocol for non- covid cold, cough congestion with green phelgm, fever

  10. The article says a safe concentration is 1.25% nasal and 2.5% oral rinse. However the products listed as links to purchase on Amazon show higher percentages. Are those products diluted down to the ranges listed in the article? Thank you

    1. 10% Povidone Iodine must be diluted by one tenth, to 1% strength before use as a mouth wash. However, povidone-iodine solutions sold as skin disinfectants are NOT suitable for gargling as they contain potentially harmful ingredients that should not be ingested.

  11. Would this be good to take after being vaccinated as well?

  12. I used diluted Betadine as a nasal spray for a few months last year. It worked well. I never got Covid but the last couple of times I used it my nose stung so I stopped using for a while. Last night I had a runny nose so I thought I would use it again. One spray up each nostril and it stung like mad and instantly I got a severe, almost migraine headache. Could I have damaged my nasal membrane from overuse in the past or could it be from old solution and what's with the headache.

    1. Did you dilute it? I used it. It works great!

    2. It’s possible you are sensitive to povidone iodine or the solution is too high a percentage for yourself. The Wellness group have physicians that can assist you with this.

  13. I just order Epothex off Amazon, it’s premixed. Still stings some but nothing close to homemade I’ve used prior.


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