Best Treatment for COVID-19 Omicron Variant?

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The World Health Organization on November 26, 2021 classified the B.1.1.529 variant, or Omicron, as a SARS-CoV-2 "variant of concern," saying it may spread more quickly than other forms of coronavirus.

The Delta variant remains dominant worldwide, accounting for 99.9% of U.S. cases, and it is not yet clear whether Omicron will be able to displace Delta, said Dr. Graham Snyder, medical director, infection prevention and hospital epidemiology at University of Pittsburgh Medical Center.

But the new variant has over 30 mutations in the part of the virus that current vaccines target. It is also suspected of driving a spike in new infections in South Africa. 

Omicron variant

COVID-19 Omicron Variant Treatment?

According to WHO, individuals are reminded to take measures to reduce their risk of COVID-19, including proven public health and social measures such as wearing well-fitting masks, hand hygiene, physical distancing, improving ventilation of indoor spaces, avoiding crowded spaces, and getting vaccinated.

Experimental antiviral pills - such as Pfizer Inc's (PFE.N) Paxlovid and Merck & Co Inc's (MRK.N) molnupiravir - target parts of the virus that are not changed in Omicron. They will work as effectively against the new variant because these drugs do not target the spike protein – they work by stopping the virus from replicating. However, there is a bigger risk that monoclonal antibodies, such as Regeneron’s treatment, could fail or partially fail because they target parts of the virus that will have mutated. 


HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung (15 Dec 2021)

One thing that could explain why Omicron is mild is that it has a much harder time replicating in the lower airways (lungs) than the upper airways (trachea and nasal cavity). Meaning, for a virus to fill up lungs with fluid, as the original and Delta COVID strains did, it needs to be able to invade the cells in the lungs by replicating itself. A study from Hong Kong sought to see how Omicron compared to its two viral siblings in that regard:

Notice that this is LOG SCALE. Each gradation is 10X the last. This shows that Omicron replicates 10 times slower in the lungs.


Ivermectin for Omicron Variant 

Since the Omicron variant is newly discovered, there's little evidence to prove whether any treatment is effective against this variant.

Theoretically, drugs that target parts of the virus that are not changed in Omicron such as antivirals like Molnupiravir and Paxlovid might still work. As mentioned above, they will work as effectively against the new variant because these drugs do not target the spike protein – they work by stopping the virus from replicating. 

Ivermectin, has multiple mode of actions against the COVID-19 virus in general (not Omicron variant) as listed and explained in this review paper.

A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications.

For early out-patient treatment protocol, check out FLCCC (Front Line COVID-19 Critical Care) Alliance I-MASK+ Protocol.

Do take note that ivermectin is not a mono-therapy and is given in combination with other treatments as per the I-MASK+ protocol mentioned above.

Most of the other component treatments in the I-MASK+ protocol have various mode of actions and may not be affected by the changes in the Omicron variant spike protein.

According to Dr John Campbell,

With ivermectin, because it’s working on so many different levels, it is improbable, to put it mildly, that a virus would mutate in a dozen different ways to avoid all those different mechanisms. We’ve talked about six mechanisms today. It’s very unlikely that we get six mutations that could dodge all of those all at the same time.

Key Takeaways

As soon as you have symptoms, consult your healthcare provider and start treatment as early as possible. If treatment is delayed i.e. after 5 days of symptoms, your chances of severe COVID are higher.

For post-covid or long covid syndrome, check out FLCCC I-Recover Post-COVID Protocol. For a simplified version of the I-MASK+ protocol, the FLCCC has also developed the I-MASS protocol.

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