Independent COVID-19 Guides, Resources and Protocols - Reducing Risk of COVID-19 Infection and Severity
Zinc Cuts COVID Death Risk by 40%? - Dr Mercola
Dr Frank Yap, M.D.
Twice-daily zinc for 15 days led to a significant reduction in death rate among people with COVID-19. It also reduced hospital stays and duration of symptoms.
Patients who tested positive for COVID-19 — including 190 outpatients and 280 hospitalized patients — received either oral zinc or a placebo twice daily for 15 days
Those taking zinc had a nearly 40% lower rate of death and admission to the intensive care unit (ICU)
Those in the zinc group had, on average, a 3.5-day shorter hospital stay while their symptoms resolved 1.9 days sooner than those who received a placebo
Research published in 2020 demonstrated that zinc is crucial to immune system function and deficiency can raise your risk of severe COVID-19 illness
Zinc has antiviral properties and acts as an immunomodulator; it also inhibits RNA synthesis and viral replication, while deficiency is associated with reduced natural killer cell function
It’s estimated that 1 in 3 Americans is deficient in at least 10 minerals, zinc included.1 Not only does this put them at risk of chronic diseases such as heart disease and diabetes,2 but it may increase risk of death or a hospital stay from COVID-19 if you’re infected.3
Zinc has been acknowledged as an essential mineral for human health since the 1970s.4 It’s the second most abundant trace mineral found in the human body,5 but your body cannot store it very well, so you need to consume foods with zinc every day to meet your body’s needs. More than 300 enzymes in your body require zinc for normal function,6 and it’s well-recognized for its role in immunity and normal immune system development.7
During the pandemic, the late Dr. Vladimir Zelenko treated thousands of COVID-19 patients using a combination of hydroxychloroquine (HCQ), azithromycin and zinc sulfate, (R) with great success.
However, the use of zinc for SARS-CoV-2 was a topic routinely flagged by COVID fact checkers as “misinformation,” so word didn’t really get out about its potential as an anti-COVID agent. Now, research once again shows zinc’s promise for keeping people healthy if they get COVID.
Zinc Twice a Day Treats COVID-19
A team of researchers with Fattouma Bourguiba University Hospital in Tunisia set out to determine zinc’s efficacy in treating adults with COVID-19. “Like in many other diseases, regulation of white blood cell production using immuno-nutrition is a novel concept that could be applied to COVID-19,” they noted. “Some molecules and nutrients such as zinc play central roles in keeping the function and integrity of the immune system.”9
They conducted a randomized, double-blind, placebo-controlled trial, during which patients who tested positive for COVID-19 — including 190 outpatients and 280 hospitalized patients (R) — received either oral zinc or a placebo twice daily for 15 days. Those taking zinc had a nearly 40% lower rate of death and admission to the intensive care unit (ICU). They also had shorter hospital stays and cut the number of days needed for their symptoms to resolve. (R)
Specifically, mortality after 30 days was 6.5% in the zinc group compared to 9.2% in the placebo group. ICU admission rate was 5.2% in the zinc group and 11.3% in the placebo group. Further, those in the zinc group had, on average, a 3.5-day shorter hospital stay while their symptoms resolved 1.9 days sooner than those who received a placebo.12
The beneficial effects of zinc were seen even in subgroups of patients, including those under 65, people with comorbidities and those who needed oxygen therapy at the start of the study. No severe adverse effects were seen. In fact, more minor adverse events occurred in the placebo group (7.1%) than in those taking zinc (3.9%). (R) The researchers concluded:14
“To our knowledge, this study is the first well powered, placebo-controlled clinical trial to report results of zinc for the treatment of patients with COVID-19.
When administered orally to patients hospitalized with COVID-19 without end-organ failure, zinc demonstrated its efficacy to prevent ICU admission and to reduce hospital length of stay; for outpatients, zinc reduced symptom duration. Zinc should be considered for the treatment of patients with COVID-19.”
Zinc Deficiency Linked to Worse COVID Outcomes
Research published in 2020 demonstrated that zinc is crucial to immune system function and deficiency can raise your risk of severe COVID-19 illness.15 “The study data clearly show that a significant number of COVID-19 patients were zinc deficient,” the researchers noted. “These zinc deficient patients developed more complications, and the deficiency was associated with a prolonged hospital stay and increased mortality.”16
There are a number of reasons why lack of zinc could worsen COVID-19 outcomes, not the least of which is zinc’s antiviral properties and action as an immunomodulator. Zinc inhibits RNA synthesis and viral replication, while deficiency is associated with reduced natural killer cell function.
Zinc supplements have long been used to treat the common cold, which is usually caused by coronaviruses, and are known to shorten the duration of symptoms and severity of respiratory infections.17 Writing in the Journal of Infectious Disease, researchers explained:18
“Interestingly, hydroxychloroquine, a drug used initially in the management of COVID-19, is an ionophore that transports zinc across the hydrophobic cell membrane.
Moreover, evidence specifically suggests that zinc supplements with antiviral drugs containing zinc ionophores precisely target and bind to SARS-CoV-2 preventing its replication within the infected host cells. Intracellularly, zinc binds with RNA-dependent RNA polymerase causing elongation inhibition and decreased template binding of the viral mRNA.”
Chances are you’ve heard of HCQ being used for COVID-19, but the real key in early treatment protocols that used HCQ is the zinc. The primary role of the HCQ is to boost zinc uptake in the cell.
In similar research, COVID-19 disease severity was associated with low levels of selenium and mortality was associated with zinc deficiency, particularly in patients with diabetes. However, the majority of those who died had a combination of selenium and zinc deficits.19
Micronutrients such as zinc, the researchers explained, “may be of high relevance for reducing SARS-CoV-2 infection risk, supporting the immune system in combating the virus, and avoiding long-term adverse health issues from COVID-19.” They added:20
“There are … a number of studies and reviews highlighting a potentially important role of Zn [zinc] supply, Zn status and Zn distribution in COVID-19, suggesting supplemental Zn as a promising therapeutic adjuvant.
Virus replication is enhanced in Zn deficiency, and supplemental Zn can inhibit virus spread and proliferation, as shown in preclinical studies and infected subjects. It is assumed that Zn deficiency predisposes to severe COVID-19, and accordingly high death rates of COVID-19 patients with Zn deficits have been observed in clinics.”
How Zinc Influences Immune Function
Zinc’s complex role in immune function continues to be unraveled. Zinc is required for the development of disease-fighting T cells and for the regeneration of your thymus, which produces T cells.
Further, a molecule inside your cells called GPR39 acts as a sensor that tracks changes in external zinc, and when the level rises, GPR39 triggers the release of a key renewal factor and thymic regeneration. In short, it appears that zinc helps the immune system to regrow immune cells.21
“What we think is going on is, as you give zinc supplementation, that gets accumulated within the developing T cells. It gets stored and stored and stored, then the damage comes along and the zinc is released,” Dr. Jarrod Dudakov, an immunologist at Fred Hutchinson Cancer Research Center, said in a news release.
“Now you have more zinc than you normally would, and it can instigate this regenerative pathway.”22 Zinc also influences immune function in a number of additional ways, including:23
How to Improve Zinc’s Effectiveness
One caveat regarding zinc is that it’s not very bioavailable. To improve its uptake in your cells, zinc ionophores are useful. These work by shuttling zinc through the cellular membrane and into the cell, which is crucial for its role in stopping virus replication. In addition to HCQ, mentioned earlier, other zinc ionophores include chloroquine, quercetin and epigallocatechin gallate (EGCG).32
When HCQ was banned from use for COVID, many wisely turned to quercetin, which is available over the counter and also has beneficial properties, such as antiviral activities,33 of its own. A number of studies have shown quercetin, when used early, also lowers your risk of hospitalization and death from COVID,34 and improves clinical outcomes.
Signs of Deficiency and Food Sources of Zinc
Common signs35 your body may need more zinc include lack of appetite, mental lethargy, impaired sense of taste or smell, frequent colds, flu or infections, hair loss36 and poor neurological function.37 Individuals at higher risk for zinc deficiency include those with malnutrition, persistent diarrhea,38 the elderly, people with inflammatory or autoimmune diseases, chronic alcoholics, vegetarians and vegans.
Although it may be necessary to supplement during illness when your body needs more zinc, I recommend trying to get your zinc from foods. Fortunately, many foods are rich in zinc, including the following:39,40,41
Base Spike Detox According to Dr Peter McCullough (in a Twitter post - July 2023): Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. A major publication is under review and editing; however, the information is far too important to hold back. Update (Nov 2023): Published on August 25, 2023 in Journal of American Physicians and Surgeons. CLICK HERE FOR THE COMPLETE PAPER > Base Spike Protein Detoxification and on November 21, 2023 in Cureus (PubMed - November 2023) I have arrived, based on the emerging scientific literature and my clinical observation, that three OTC products are essential as a triple base combination: Nattokinase 2000 FU (100 mg) twice a day Bromelain 500 mg once a day Nano/Liposomal Curcumin 5
Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough Protocol 2022 Updates: Double blind randomized controlled trial of saline solution gargling and nasal rinsing in COVID infection (Nov 2023) What really killed COVID-19 patients: It wasn't a cytokine storm, suggests study (2023) Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the pri
Well-respected North Texas cardiologist, Dr. Peter McCullough has impeccable academic credentials. He's an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough et al. Reviews in Cardiovascular Medicine, 2020 McCullough Protocol 2022 Updates: Omicron variant XBB found to be resistant to monoclonal antibody treatments ( New England Journal of Medicine . Dec 2022) How to Detox Spike Protein from Body (August 2023) As published in Dr
Is povidone iodine the next ivermectin or hydroxychloroquine? Is there any evidence that povidone iodine can treat COVID-19? Iodine 1% Nasal Spray is part of the FLCCC I-CARE early treatment protocol : Nasal spray with 1% povidone-iodine: 2-3 times a day. Do not use for more than 5 days in pregnancy. If 1% product is not available, dilute the more widely available 10% solution and apply 4-5 drops to each nostril every 4 hours. Use 1 % povidone iodine commercial product as per instructions 2–3 x daily. If 1 %-product not available, must first dilute the more widely available 10 %-solution. To make 1% povidone iodine concentrated solution from 10% povidone iodine solution, one dilution method is as follows: – First pour 1½ tablespoons (25ml) of 10% povidone/ iodine solution into a nasal irrigation bottle of
Biography Well-respected North Texas cardiologist, Dr. Peter McCullough has impeccable academic credentials. He's an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. Personal History Dr. Peter A. McCullough was born in Buffalo, New York, on the 29th of December 1962. During high school, he and his family moved to Wichita Falls in Texas and later settled in Grapevine. He has lived and worked in various parts of the United States, including Washington and Michigan, and he now resides in Dallas, Texas. McCullough Protocol 2022 Dr Peter McCullough Early Treatment Protocol
Treatment should start based on clinical suspicion as soon as possible, preferably within the first 3 days of symptoms. Perform PCR testing, but do not withhold treatment pending results. 'Early' treatment will make significant difference in outcome as opposed to late treatment. To assist all who are having difficulty finding pharmacists to fill prescriptions for ivermectin or hydroxychloroquine (Plaquenil) for preventing or treating COVID-19 , check out Find a Pharmacy to fill Ivermectin (US). See the directory of professionals in US below. Directory of Doctors (by State) Prescribing Effective Outpatient COVID-19 Therapy USA MULTIPLE STATES (Telemedicine or online consultation) The Wellness Company ( twc.health ) Medical Specialty: Family Medicine, Functional Medicine Supported Protocols: I-PREVENT (COVID Protection), I-CARE (Early at-home treatment), I-RECOVER (Long COVID and Post-Vaccine treatme
Over the last three years, the COVID-19 pandemic has transformed almost every aspect of our lives before we've had time to stop and question it. Although no official definition exists for post-COVID-vaccine syndrome, a temporal correlation between a patient receiving a COVID-19 vaccine and beginning or worsening of clinical manifestations is sufficient to diagnose as a COVID-19 vaccine-induced injury, when the symptoms are unexplained by other concurrent causes. Dr. Paul Marik and Dr. Pierre Kory are pleased to introduce the I-RECOVER: Post-Vaccine Treatment protocol, designed to help people who have experienced adverse symptoms after a COVID vaccine. Kory and Marik are both part of the FLCCC, which was founded in 2020 to share early treatment protocols for COVID-19. Kory is an ICU specialist, triple board certified in internal medicine, critical care and pulmonary medicine. He now runs a private tele-health practice specializing in the treatment of COVID-19, so-called
SELF-HELP without a Doctor ( source ) Zinc 50 mg daily (can take half twice daily if upset stomach) Quercetin 500 mg twice a day three times a day if sick (switch to HCQ/IVM if available) Vitamin D3 40,000-50,000 for five days Melatonin 5 mg - 20 mg nightly for 14 days stomach) Pepcid 40-80 daily 14 days – women or Cimetidine 400 daily -men Full Aspirin (325 mg) daily one month N acetyl cysteine (NAC) Up to 2000-2400 mg 1-2 days, then 1000-1200 mg for a week Treatment: Latest Prescriptions ( source ) Monoclonal Antibodies: outpatient, FDA approved, early treatment, within 10 days Only. Note and Update: Omicron variant XBB found to be resistant to monoclonal antibody treatments ( New England Journal of Medicine . Dec 2022) HCQ 200 mg twice a day 7 days or IVM (weight based 0.4/kg) 20-36 mg daily 2-5 days Fenofibrate (Tricor – anti-lipid) 145 mg daily (inflammatory/cytokine phase. Antioxidant) Cyproheptadine (Periactin – antihistamine) 4 mg BID for 14 days (cytokine phase) D
A November 2023 study (Yale University) shows some of the most common chronic symptoms among people who began experiencing the problems after receiving a COVID-19 vaccine. The most common symptoms were exercise intolerance, excessive fatigue, numbness, brain fog, and neuropathy, researchers reported in the paper. Insomnia, palpitations, myalgia, tinnitus, headache, burning sensations, and dizziness were also experienced by at least half of the participants in the study, which was funded in part by the U.S. National Institutes of Health (NIH). Participants reported a median of 22 symptoms, with a ceiling of 35. The study focused on people "who report a severe, debilitating chronic condition following COVID-19 vaccination" that "began soon after COVID-19 vaccination and persisted in many people for a year or more," the researchers said. The study was led by Dr. Harlan Krumholz of the Department of Internal
Dr Peter McCullough's Spike Detox Protocol (Substack) According to Dr Peter McCullough's substack article : For several weeks I have been messaging the scientific community and the public about an approach addressing the burden of SARS-CoV-2 Spike protein in tissues and organs in the human body that is largely responsible for post-COVID and vaccine injury syndromes. No therapeutic claims can be made since large, prospective, double-blind randomized, placebo-controlled trials have not been completed on any of the compounds mentioned in this paper. I checked clinicaltrials.gov and no such trials have been planned. The Biden HHS US Action Plan for Long-COVID Research has pumped a billion dollars into long-COVID research and no new therapies have emerged. HHS, NIH, CDC, FDA have not recognized the larger issue of vaccine damage to the body. At three and one half years into the pandemic and two and a half years into the COVID-19 vaccine debacle, myself and my clinic partners formul