BA.5 Subvariant Uptick, Herd Immunity and Q & A 30 on America Out Loud PULSE

Hopes of Covid-19 Reprieve Fade as BA.5 Subvariant Takes Over  –  ran in the Wall Street Journal

UPTICK | BA.5 is estimated to represent more than one in three recent U.S. cases that are averaging just more than 100,000 a day, CDC data show. The true number of infections may be roughly six times as high, some virus experts said, in part because so many people are using at-home tests that state health departments largely don’t track.


BOOSTERS | Biden Administration health officials said Tuesday that BA.5 has the potential to push the number of infections higher in the coming weeks. They urged eligible people to get vaccine booster shots to lower the risk of hospitalization and death, and not to wait for potential updated boosters targeting Omicron subvariants.

MORE MASKING | New York City last week urged people to resume masking in public, indoor settings and around crowds outside. Los Angeles County’s public health department said rising Covid-19 hospital admissions mean the county also could soon reach high community prevalence and that officials would reinstate a mask mandate if the county stayed at that level for two weeks.

Covid herd immunity hasn’t panned out: Why we are seeing surges when most Americans have been vaccinated or infected – Science, the Grid.

The details of when and how this seemingly magical threshold would be crossed were fuzzy. Some scientists who study viruses thought only 20-some percent of the population needed to be immune; others estimated it’d be closer to 90. A minority of experts wanted to reach herd immunity as quickly as possible by letting the virus rip through the population rather than wait for vaccines to become available. But no matter the number or method, the concept of herd immunity represented a framework through which public officials and the media (including me) could understand what it would take for the threat to end.

Here are a few examples of the kind of questions that we will address on the program today ⏤

Lisa – I was wondering if Dr. Mccollough would be kind enough to provide this request? As you know, a lot of areas are moving into the high transmission with the current variant and with all the disinformation still out there, I think it would be so helpful if Dr. Mccollough could give his thoughts on the following: What are the symptoms of this strain? Who is considered high risk these days? What is the general treatment for high risk and non-high risk? Who and when should we wear masks?

Annabelle – My bf received 2 doses of the Moderna vaccine plus a booster. We are close to getting engaged, but I have concerns on how this could impact myself or our future children. I know not much is known about the future impact this vaccine will have on individuals but is this something I should worry about? Could this cause health issues for our children?

Joycelyn – My brother (age: 67 yrs) had the Delta version almost a year ago, was hospitalized, and by the grace of God, made it out alive! However, he is still having trouble getting his energy back and seems to be very susceptible to (non-Corona) viruses going around his work. He takes vitamins and prescribed meds: is diabetic and had stents put in three years ago. None of his regular doctors seem to address how covid affected his long-term health. He did NOT take the shot. I hear there are “long covid” doctors now, but not sure how to go about finding one. Can you help? He lives in the Austin, Texas, area.

Robyn – You say that the program is for educational purposes only, which I completely understand. But you also say to rely on your MD for proper information and treatment. The problem with this is that so many, if not most, doctors buy into the narrative for treating Covid. I am a retired RN who has watched doctors be bought and paid for by their organizations for many years. It’s so much worse now. At least four doctors in my area have died unexpectedly and suddenly in this past year or so. One of them, who was supposedly a healthy man who mowed his yard then came into the house, sat down and had a heart attack, and died, Was a friend of the physician I worked for. When I asked him if it was possible that vaccination caused this, he simply said oh no, he had a heart attack! I’m seeing more and more obituaries for young people who have had heart attacks or Just died suddenly in their sleep. Why is no one questioning this?

Karen – What diagnostics do you recommend for chronic illnesses after vaccination?

Jim – When will there be a formal release of adverse events from the vaccines that detail mortality and other injuries that don’t get censored?

Elaine – My husband and I are not jabbed and trying to conceive? I have seen a lot of people having a hard time with getting pregnant. Do you know why? Any fertility suggestions?

Jesse – I just wanted to share my recent experience, and perhaps a word of caution. I was a nurse at a clinic in the Midwest, and my facility announced a vaccine booster requirement taking effect on March 1, 2022. Having heard Dr. McCullough and others talk about resisting these policies and mandates, I took a stand and took my leave. Ever since, my career and life have been derailed, and I spend every day wishing I would have just taken the shot. My advice to those who speak publicly on these things is to emphasize the importance of making personal decisions based on individual needs. I made my decisions, I’m not blaming anyone else, but my decisions were greatly influenced by this show. I wouldn’t wish what I’ve been experiencing on anyone.


 

Source: https://www.americaoutloud.com/ba-5-subvariant-uptick-herd-immunity-and-q-a-30-on-america-out-loud-pulse/


Update: Effectiveness of Monoclonal Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants 

A lab study published in July 2022 (NEJM) using the live-virus Focus Reduction Neutralization Testing (FRNT) method revealed that bebtelovimab seems to be the most promising monoclonal antibody against the BA 5 subvariant.


Overall, the study data also revealed that the three antiviral drugs remdesivir, molnupiravir, and nirmatrelvir (Paxlovid) may still have therapeutic value against the sublineages BA.2.12.1, BA.4, and BA.5 of SARS-CoV-2 omicron variants.


Do take note of the limitation of this study as this is a non-clinical study (not in humans). There is lack of clinical data on the efficacy of these monoclonal antibodies and antiviral drugs for the treatment of patients infected with BA.4 or BA.5 subvariants. Therefore, the selection of monoclonal antibodies or anti-virals to treat patients who are infected should be carefully considered based on the potential risks as compared to its potential benefits.


Related: 


Omicron BA 4 and BA 5 Subvariants: Symptoms and Treatment


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