Formerly The COVID Advisor — evidence-based analysis of Long COVID, immune injury, and post-viral disease
Unexpected Comeback of Hydroxychloroquine 2022
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Editorial Team
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If you have followed the development of early treatment protocols for COVID-19, you will be aware that for well over a year, Ivermectin was the central agent in the FLCCC protocol, for prevention and early treatment. Ivermectin is also part of the hospital level protocols.
Very early on, as discussed in this interview with Professor Varon, Hydroxychloroquine was present in the protocol, but it was dropped mid-2020.
This non-inclusion of Hydroxychloroquine appears to have been in part due to the bad publicity that hydroxychloroquine was suffering from, as it was targeted by the mainstream media, especially in relation to the presidential campaign in the US in 2020.
Comeback of Hydroxychloroquine
This January 19, 2022; it’s therefore a bit of a surprise to see Hydroxychloroquine to re-appear in the FLCCC prevention and early treatment protocol.
The move follows the experience of several frontline doctors who found that Hydroxychloroquine is particularly useful to deal with Omicron, in combination with Ivermectin and other agents, as indicated in the protocol.
Hydroxychloroquine and Clinical Evidence (Updated)
As of February 2022 there have been more than 30 studies of Hydroxychloroquine for early treatment with an overall average improvement of 64% as compared to the control groups.
Hydroxychloroquine (HCQ) is not effective when used very late with high dosages over a long period (RECOVERY/SOLIDARITY), effectiveness improves with earlier usage and improved dosing. Early treatment consistently shows positive effects. Negative evaluations typically ignore treatment time, often focusing on a subset of late stage studies.
Here’s a chart from c19early.comthat shows that hydroxychloroquine performs better than ivermectin when given as early treatment in terms of risk reduction of dying from COVID-19:
The overall improvement for hydroxychloroquine is better than ivermectin (for early treatment); 74 % vs 44 % in terms of death rate. Importantly, hydroxychloroquine needs to be given 'early'.
The difference in terms of effectiveness for hydroxychloroquine is distinctly different when given early vs late treatment (64% vs 20%), as shown in the summary chart below:
The evidence tracking on Hydroxychloroquine versus COVID-19 is available at c19hcq.com (constantly updated).
Base Spike Detox According to Dr Peter McCullough (in a X/Twitter post): Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. I have arrived, based on the emerging scientific literature (1) and my clinical observation, that three OTC products are essential as a triple base combination: Nattokinase 2000 FU (100 mg) twice a day — take on an empty stomach Bromelain 500 mg once a day — take on an empty stomach Nano/Liposomal Curcumin 500 mg twice a day — take with food How long should I take this? Dr. McCullough recommends a minimum of 3 months , with many patients requiring 6–12 months or longer. Progress can be tracked via a spike protein antibody test (available through Labcorp in m...
Immune Systems Advisor · Integrative Medicine White Paper · Open Access Authors: OneDayMD Editorial Team (synthesis and editorial adaptation) · Original protocols: Marik P, Kory P (IMA/FLCCC, 2022–2024); McCullough PA (Cureus, 2023) · Published: March 2023 · Last updated: June 2026 · DOI: n/a (educational synthesis) Evidence Tier Key: TIER 1 RCT / systematic review TIER 2 Observational / cohort TIER 3 In vitro / mechanistic TIER 4 Expert consensus / clinical observation ⚠ Medical Disclaimer — Please Read First. This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The protocols described involve supplements with significant anticoagulant activity. Always consult a licensed physician before starting, especially if you take blood thinners, are pregnant or breastfeeding, have a bleeding disorder, or...
A clinician-developed regimen of nattokinase, bromelain, and curcumin for clearing persistent SARS-CoV-2 spike protein — with dosing, safety guidance, monitoring, and full FAQ. Editorial Team | Originally published March 2023 | Last updated June 30, 2026 | Reviewed against published literature and Dr. McCullough's 2025 clinical updates ⚠️ Medical Disclaimer — Please Read First This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The Base Spike Detox protocol involves supplements with significant anticoagulant activity. Always consult a licensed physician before starting , especially if you are taking blood thinners, are pregnant or breastfeeding, have a bleeding disorder, or are treating a child. For a virtual consultation with a physician familiar with this protocol, vis...
Dr. McCullough explained (1) that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. Spike Protein Protocol Personalizer Based on Dr. Peter McCullough's Base Spike Detox & FLCCC I-Recover Frameworks ⚠ Medical Disclaimer: This tool is...
Can you remove spike proteins from your body? Dr. Paul Marik and Dr. Pierre Kory are pleased to introduce the I-RECOVER: Post-Vaccine Treatment protocol, designed to help people who have experienced adverse symptoms after a COVID vaccine. Kory and Marik are both part of the FLCCC*, which was founded in 2020 to share early treatment protocols for COVID-19. Kory is an ICU specialist, triple board certified in internal medicine, critical care and pulmonary medicine. He now runs a private tele-health practice specializing in the treatment of COVID-19, so-called "long-COVID" and post-vaccine syndrome. *The FLCCC Alliance is now the Independent Medical Alliance Note that there are significant overlaps between the symptoms and features of long COVID/long-hauler syndrome and post-vaccine syndrome. However, a number of clinical features appear to be characteristic of post-vaccine syndrome; most notably, severe neurological symptoms appear to be more common following vaccination. To c...
Introduction The rapid development and deployment of COVID-19 vaccines have been monumental in combating the global pandemic, saving countless lives and enabling societies to regain a sense of normalcy. Central to the efficacy of many of these vaccines, particularly mRNA and viral vector-based ones, is the spike protein—a key component of the SARS-CoV-2 virus that facilitates its entry into human cells. By instructing the body to produce a version of this protein, vaccines train the immune system to recognize and neutralize the virus without causing illness. However, as vaccination campaigns expanded, so did public curiosity and concern about the spike protein's role, fueled by a mix of scientific complexity, misinformation, and distrust. For years, the public was told that COVID-19 mRNA vaccine components degraded rapidly—within days to weeks. Hulscher, McCullough, and colleagues' 2026 peer-reviewed study challenges that assumption, reporting findings ...
Reviewed by: OneDayMD Editorial Team | Last updated: July 16, 2026 (includes link to Dr Paul Marik and Dr Justus Hope latest Substack article related to "turbo cancer") COVID-19 vaccines and boosters — both mRNA and non-mRNA — pose an increased risk of six types of cancer and a 27% higher risk of cancer overall , according to a recent South Korean study of over 8 million people. Four South Korean researchers published the report last week as a letter in Biomarker Research, a Springer Nature journal. According to the study, COVID-19 vaccines and boosters are associated with a higher risk of breast, colorectal, gastric, lung, prostate and thyroid cancer, across all vaccine types and age groups. Mainstream medical commentators were quick to dismiss the findings, with MedPageToday describing it as “flawed.” But other medical and scientific experts disagreed. “In plain terms: both major COVID-19 vaccine platforms ...
⚠ Medical Disclaimer — Please Read First This article is for educational and historical reference only and does not constitute medical advice, diagnosis, or treatment. It describes a COVID-19 outpatient protocol first proposed in 2020 by the late Dr. Vladimir Zelenko, alongside what current clinical research (through 2026) shows about each component . Hydroxychloroquine and ivermectin are prescription-relevant medicines with real drug interactions and side effects; large randomized trials completed since 2021 have not shown a meaningful treatment benefit for COVID-19 (details below), and neither drug is recommended for this use by the FDA, WHO, or NIH COVID-19 Treatment Guidelines. Always consult a licensed physician before starting any supplement or medication regimen , especially if you are pregnant or breastfeeding, have a cardiac, kidney, or thyroid condition, or take other prescription medications. For a virtual consultation with a physician, visit The Wellness Company . ...
America Out Loud - Our show this week is an excerpt from the BS Free MD Podcast, where Drs. May and Tim Hindmarsh speak with cardiologist and internist Dr. Peter McCullough, a leading scientist investigating long COVID and post-vaccine syndromes. The conversation dives into the evolving understanding of spike-protein–related illness, McCullough’s ground-breaking research linking persistent spike protein exposure to long-term disability, and his practical “McCullough Protocol-Based Spike Detoxification” approach. Dr. May Hindmarsh shares her personal struggle: after severe COVID infections, menopause, and hormonal treatment, her health deteriorated—with rapid heart rate, mast-cell activation, histamine sensitivity, anxiety, insomnia, and gastrointestinal distress. She later discovered her blood test showed sky-high anti–spike protein antibody levels (>12,000 U/mL on LabCorp testing). McCullough explains that such titers correlate with circulating spike protein fragments, even years ...
Medical Disclaimer: The information provided in this article is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting any supplement regimen, especially if you are taking blood thinners or have pre-existing health conditions. Key Takeaways: Base Spike Protein Detox Core Protocol: A triple combination of Nattokinase, Bromelain, and Curcumin forms the core "Base Spike Detox" protocol published in peer-reviewed literature. Micro-Clot & Cellular Support: NAC and Omega-3s support the breakdown of micro-thrombi and promote endothelial health. Immune & Gut Resilience: Vitamin D3/K2, Zinc, Resveratrol, Quercetin, Melatonin, and Probiotics aid targeted immune balance and gut-brain axis recovery. Duration: Protocols typically require 3 to 12 months for noticeable cellular recovery under phy...
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