Vitamin D May Improve Post-COVID-19 Vaccine Chronic Fatigue Syndrome: Study (2025)

By Editorial Team -

The study titled, Efficacy of vitamin D replacement therapy on 28 cases of myalgic encephalomyelitis/chronic fatigue syndrome after COVID-19 vaccination, was published in Nutrition (2025):

Background

Prolonged symptoms have been reported following both COVID-19 infection and vaccination, with some cases leading to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Of 80 patients presenting to our hospital with postvaccination syndrome, 28 met the diagnostic criteria for ME/CFS. We conducted a retrospective study on these 28 patients.

Methods

We measured serum 25-hydroxyvitamin D levels in 28 patients who developed ME/CFS after COVID-19 vaccination between August 2022 and February 2024. Vitamin D replacement therapy included dietary counseling, sun exposure recommendations, and oral vitamin D supplementation. We evaluated changes in blood vitamin D levels and symptom improvement.

Results

At initial visit, 27 of 28 patients diagnosed with ME/CFS had insufficient or deficient serum 25-hydroxyvitamin D levels (16 ± 4 ng/mL, mean ± SD). Following vitamin D replacement therapy, we observed an increase in blood vitamin D levels (28 ± 5 ng/mL) associated with a decrease in ME/CFS diagnostic symptoms (from 10.3 ± 2.1 to 3.3 ± 2.0). Notably, 23 of 28 patients (82%) no longer met ME/CFS diagnostic criteria after the therapy. Among the symptoms, sleep problems showed the most improvement (71%), followed by autonomic symptoms (68%).

Conclusions

For patients developing ME/CFS after COVID-19 vaccination with insufficient or deficient vitamin D levels, appropriate vitamin D replacement therapy under medical guidance may lead to symptomatic relief. We are preparing a randomized controlled trial to evaluate the efficacy of vitamin D replacement therapy in individuals with ME/CFS who have developed vitamin D deficiency following COVID-19 infection or vaccination. 



Here are the key findings:

High Prevalence of Vitamin D Deficiency in Post-COVID-19 Vaccination ME/CFS Cases

  • 27 out of 28 patients (96%) had insufficient or deficient vitamin D levels before treatment.
  • Mean baseline vitamin D level: 16 ± 4 ng/mL (deficient range).
  • Vitamin D deficiency may be linked to immune dysfunction and post-vaccine complications.

COVID-19 Vaccine Identified as a Major Suspected Trigger

  • 68% of patients developed ME/CFS symptoms immediately after receiving a COVID-19 vaccine.
  • The onset of ME/CFS symptoms occurred after 1–6 doses of the vaccine, with the most cases appearing after the third dose (46%).
  • 82% of patients had no history of prior COVID-19 infection, suggesting vaccination—not infection—was the primary trigger.
  • Some patients faced medical gaslighting, as previous doctors dismissed their post-vaccine symptoms.
  • Due to suspected vaccine-induced ME/CFS, patients were advised not to receive further COVID-19 booster shots.

Significant Symptom Improvement After Vitamin D Therapy

  • 82% (23 out of 28) of patients no longer met ME/CFS diagnostic criteria following vitamin D replacement.
  • Most improved symptoms:
    • Sleep problems (71% improvement)
    • Autonomic symptoms (68% improvement)
    • Post-exertional malaise (54% improvement)
  • Pathologic fatigue showed the least improvement (21%), suggesting deeper systemic dysfunction in post-vaccine ME/CFS.

Vitamin D Protects Against COVID-19 mRNA Injection-Induced Myocarditis

Vitamin D has also demonstrated potential therapeutic benefits for other adverse events following COVID-19 vaccination. Notably, Tsang et al reported that vitamin D protects against COVID-19 mRNA vaccine-induced myocarditis:

NEW STUDY - Vitamin D Protects Against COVID-19 mRNA Injection-Induced Myocarditis
Nicolas Hulscher, MPH




by Nicolas Hulscher, MPH

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Given the growing evidence of vitamin D’s role in mitigating post-vaccine complications, large-scale, double-blind, placebo-controlled trials are urgently needed to further evaluate its efficacy in treating COVID-19 vaccine injury syndromes.

About the Author: Nicolas Hulscher, MPH, Epidemiologist and Foundation Administrator, McCullough Foundation.


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