Autophagy Heals Damage from Spike Protein, Doctor Said

Maybe you’ve never heard the word “autophagy” before. Or maybe you’ve been wondering for years what it means.

Autophagy, also called autophagocytosis, refers to a process in cellular biology that has sparked interest in recent years because of its implications for medical science and human health.

Figure 1 Analog of Autophagy-Waste Recycling System

“Auto” means self in Greek. “Phagy” means to eat or to devour. So, “autophagy” is the act of eating one’s self. And this is exactly what cells do to keep healthy—especially when they are starving.

Each cell has organelles (cellular organs) called lysosomes that function like a stomach. They digest and break down cellular waste and invading viruses and bacteria. Different forms of autophagy make use of the lysosome’s digestive enzymes to break down cellular components at different scales.

At a crucial level, autophagy allows for the orderly recycling of cellular components, turning them into the building blocks for future cells.

Cells have a kind of life cycle or job cycle. At a given time, any cell in the body is focused on a specific task, explained Dr. Henry Ealy, a naturopathic physician based in Phoenix, Arizona, during a talk he gave at a healthcare conference in Sedona.

These cell activities include:

  • Nutrient absorption
  • Energy production
  • Making enzymes
  • Assembling and distributing proteins
  • Autophagy
  • Replication

Autophagy, Dr. Ealy said, is the stage many cells don’t get into every day. That’s because the cells never have a break from tasks triggered when we eat food.

“The most important thing you can do every single day to make sure you are getting into autophagocytosis,” Dr. Ealy said, “is to be hungry.” Hunger, Ealy insisted, is a key strategy that helps the body heal.

You can think of cells like little factories, in a way. They take all the nutrients we eat and turn them into our body and the processes that drive our body. When we don’t eat, these little cellular factories have a chance to tidy up, replace broken machinery, and use up waste material. This is autophagy.

Why Do Cells Need Autophagy?

During autophagy, or autophagocytosis, the lysosomes increase a cell’s life span by breaking down and recycling cellular materials. This process also helps the cell balance its energy demands when it is stressed.

A Belgian biochemist, named Christian René de Duve, is credited as the person who invented the term autophagocytosis. De Duve was also the first scientist to show evidence that lysosomes are involved in this process. For his pioneering research (including that on lysosomes), he was honored with the Nobel Prize in Physiology or Medicine in 1974.

In fact, understanding autophagy was so important to medicine, that in 2016, the Nobel Prize was awarded to another pioneer in this field: Japanese molecular biologist Dr. Yoshinori Ohsumi.

Scientists have found evidence that there are at least three kinds of autophagic activity that take place within our cells and that each plays a slightly different role helping cells maintain themselves. Those are macroautophagy, microautophagy, and chaperone-mediated autophagy.

Macroautophagy: This is a process in which parts of the cytoplasm inside the cell are sequestered—basically encapsulated—and then delivered to lysosomes to be broken down.

During the first phase of this process a phagophore, or isolation membrane, is formed. Once the cellular material is sequestered, it fuses with the lysosomes. Then lysosomal enzymes degrade its contents, according to a 2008 explanatory article published in the journal Cell.

Microautophagy: In microautophagy, which a research review published in Cellular and Molecular Life Sciences, has described as “a lesser-known self-eating” process, components of the cell are engulfed directly by small autophagic tubes, also called invaginations, found in the lysosomal membrane.

This kind of autophagy is most often seen when cells are nitrogen deficient. According to these scientists, “microautogaphy is coordinated with and complements” other types of self-eating pathways.

Chaperone-Mediated Autophagy: This third kind of autophagy may be responsible for the degradation of 30 percent of cytosolic proteins when cells experience nutrient deprivation, according to a 2007 review article by the late Dr. James Dice, who was a professor of physiology and a specialist in aging and autophagy at Tufts University’s School of Medicine.

The cytosol, which is a component of cytoplasm, is the substance that fills the interior of the cell. Cytosolic proteins are involved in protein modification, mRNA degradation, and metabolism, among other functions. This kind of autophagy involves molecular chaperons, substances in the cytosol that undo proteins within the cytoplasm and usher them across the membrane of the lysosomes where the autophagy is completed.

Autophagy and Cellular Energy

Autophagy is particularly important during starvation scenarios when cells are in nutrient-poor environments and need cellular ingredients as building blocks and to support ATP production, according to a molecular biology research paper published in 2010.

ATP, if you remember back to Biology 101, stands for adenosine triphosphate. If our cells are little factories, ATP is the fuel they run on. This organic compound, which is found in all living organisms (including the most primitive unicellular beings), provides energy to living cells.

ATP consists of three components: adenine, ribose, and triphosphate. You can also think of ATP as molecular money—the currency that is needed to transfer energy from cell to cell. ATP is made by tiny organelles inside our cells called mitochondria that are considered “the powerhouses” of the cells.

Autophagy breaks cellular components down to  molecules, such as monosaccharides, fatty acids, and amino acids that can be used to produce ATP.

Autophagy Versus Cancer

Given that it supports the production of more ATP, scientists have long believed that autophagy helps cells survive. While this appears to be true, autophagy also plays a key role in cell death by eliminating damaged organelles and protein aggregates, according to a team of scientists in Massachusetts, writing in the journal Perspectives in Biology in 2012.

Cancer is the result of unchecked growth of abnormal cells. Appropriate autophagy is important to stopping tumor growth, inhibiting cancer cell survival, and clearing cancer cells.

“The modulation of autophagy plays dual roles in tumor suppression and promotion in many cancers,” wrote two Korean biochemists in a 2018 review article published in the peer-reviewed International Journal of Molecular Science.

Although autophagy can contribute to the resistance to anti-cancer agents, “autophagy is a promising potential therapeutic target in cancer treatment,” the authors concluded.

Autophagy Versus Spike Proteins

Because autophagy breaks down broken cellular parts and helps our cells rebuild with better ingredients, so to speak, it is a critical process when it comes to cellular damage, like that associated with spike proteins caused by the COVID-19 virus and the vaccines mandated in regards to it.

According to Dr. Ealy, because it jumpstarts autophagy, “hunger is healing.” He has observed that depriving the body of nutrients for a three-day water-only no-calorie fast can help resolve the symptoms of a variety of health conditions, Dr. Ealy said in his October 15, 2022 talk in Arizona.

Fasting, Dr. Ealy claimed, can help reverse damage caused by COVID-19 vaccines and other toxic exposures.

Dr. Ealy gave the example of a patient who felt very sick after receiving the first Moderna shot. Five weeks later, she felt better. But after the second shot, which she was advised to get, her health “started going haywire.”

Her legs, arm, and wrists started to hurt. The joint pain was so bad that she found walking upstairs difficult. “I was having heart palpitations,” the patient recounted in a video interview Dr Healy played during his presentation. “I was really afraid I was going to die.”

She had bloodwork done by her general practitioner about a week after the second shot. Her doctor was concerned by the numbers.

This patient had been previously diagnosed with hypothyroidism (a pathologically slow thyroid). Even so, her thyroid stimulating hormone skyrocketed to abnormally high levels, even for her condition.

Her general practitioner advised that she report the side effects she experienced to the Centers for Disease Control and Prevention’s Vaccine Adverse Effects Reporting System.

“My suspicion was that the mRNA sequences were still viable and still producing spike protein,” Dr. Ealy said.

Although the CDC said that mRNA vaccines would not change human DNA, a recent study from researchers at Lund University in Sweden found the opposite: this in vitro study showed that vaccine mRNA was quickly taken into human liver cell line where the mRNA subsequently wrote itself onto the liver cell line DNA.

Dr. Ealy believed his patient’s symptoms, including the joint pain, muscle weakness, and heart palpitations, were because her body was still producing the SARS-CoV-2 spike proteins, coded by the vaccine mRNA.

“Fasting is the off-switch,” Dr. Ealy said. After studying cellular biochemistry, Dr. Ealy believes that a three-day water fast, which compels the cells to engage in autophagy, can help the body clear these spike proteins, whether they are from a SARS-CoV-2 infection itself or from an mRNA vaccine.

After the three-day fast, Dr. Ealy prescribed eleven days of targeted nutrients and enzymes to further help his patient break down any circulating spike protein, he explained.

It took this patient three cycles of fasting followed by nutritional healing before she started to feel better. But the results were startling. After those cycles when she had her blood redrawn, her doctor was astonished by how healthy her hormone levels were. They were so normal, in fact, that her doctor wondered if the protocol had reversed her autoimmune condition.

“Every time I did the three-day water fast, I always felt so good,” Dr. Ealy’s patient said.

Fasting isn’t something conventional practitioners and patients associate with well-being. And a three day water fast isn’t something that should be taken lightly and without medical supervision.

But when it comes to well-being on the cellular level, Dr. Ealy insists fasting—and inducing autophagy—is an important way to help the body heal.

FLCCC’s First Line Treatments

Since long COVID and post-vaccine symptoms are both associated with spike protein presence, the first line treatments recommended by the FLCCC therefore focus on two main steps.

The first step is to remove spike protein, the second step is to reduce its toxicity. The body will then heal itself, and this is “the primary treatment goal,” said Marik.

Most of the first line treatments have focused on clearing out the spike protein by reactivating autophagy—a process that is downregulated by spike protein.

Lifestyle implementations can boost autophagy through intermittent fasting, and photobiomodulation. Photobiomodulation can be done by exposing oneself to the sun, since sunlight contains infrared rays that boost autophagy in cells.

Intermittent Fasting

Fasting is suggested as a potential first-line treatment for long COVID and post-vaccine symptoms, according to the Front Line COVID-19 Critical Care (FLCCC) Alliance, a prominent medical group focusing on these conditions. 

The purpose of fasting in these cases is to stimulate autophagy, a process that breaks down and recycles proteins, including COVID-19 spike proteins.

FLCCC doctors believe that spike proteins, whether from the infection or the vaccine, play a significant role in patients’ symptoms. These spike proteins can lead to inflammation, micro-clotting, mitochondrial dysfunction, autoimmunity, neurological issues, and other complications.

Chaperone-mediated autophagy, which specializes in protein degradation, typically activates after 24 hours of fasting. Therefore, the FLCCC recommends prolonged fasting of 72 hours or more if tolerated.

Scott Marsland, a nurse practitioner treating long COVID and vaccine injury said that patients often see an improvement in their brain fog in the later hours of their 72-hour fast, further adding that fasting has likely helped alleviate all known symptoms of long COVID and vaccine injury.

Board-certified internist Dr. Syed Haider, on the other hand, said that he has had patients who experienced a complete reversal of symptoms during prolonged fasts. 

Although there is no definitive test for spike protein reduction, diligent adherence to a fasting schedule, particularly with prolonged fasting, has shown decreased spike protein levels, according to Marsland’s observations.

On the flip side, autophagy cannot remain continuously activated all the time. You also need to allow the cells to rebuild and rejuvenate, which occurs during the refeeding phase, which is why cyclical fasting and feeding is so important.

Activating autophagy is a double-edged sword. One the one hand, the process clears toxic or infectious materials from cells. On the other hand, if the autophagy process goes beyond 'recycling' and clearing out proteins, it can start to destroy the cell, leading to cell death. This means that autophagy must be carefully manipulated to avoid the death of non-renewable and irreplaceable cells such as brain cells.

However it should be noted that intermittent fasting is not recommended for people younger than the age of 18, as it can prevent growth. Pregnant and breastfeeding women are also not recommended to fast intermittently. People with diabetes and kidney disease are also recommended to check with their primary care physicians before considering intermittent fasting.

While intermittent fasting may not be suitable for everyone, there are other treatment options that can boost autophagy and reduce spike protein toxicity.

About the Authors:

Jennifer Margulis, Ph.D., is an award-winning journalist and author of “Your Baby, Your Way: Taking Charge of Your Pregnancy, Childbirth, and Parenting Decisions for a Happier, Healthier Family.” A Fulbright awardee and mother of four, she has worked on a child survival campaign in West Africa, advocated for an end to child slavery in Pakistan on prime-time TV in France, and taught post-colonial literature to non-traditional students in inner-city Atlanta.

Joe Wang, Ph.D., was a molecular biologist with more than 10 years of experience in the vaccine industry. He is now the president of New Tang Dynasty TV (Canada), and a columnist for the Epoch Times.


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