Dr. Peter McCullough's Spike Protein Detox Protocol: Base Spike Detox Explained (2026)
An evidence-tiered review of the nattokinase, bromelain and curcumin regimen proposed by Dr. Peter McCullough: what it is, what the research does and does not show, how to use it safely, and how (not) to monitor it. By OneDayMD Editorial Team | Originally published March 2026 | Last updated October 18, 2026 | Sources reviewed through October 2026 | Next scheduled review: April 2027 Quick answer The McCullough Base Spike Detox is a clinician-proposed regimen of nattokinase (2,000 FU twice daily), bromelain (500 mg daily) and nano/liposomal curcumin (500 mg twice daily) intended to break down persistent SARS-CoV-2 spike protein. [1] Laboratory studies show nattokinase can degrade spike protein in cell and test-tube systems TIER 3 [2] [3] , and spike antigen does persist in a minority of people for months after infection TIER 2 [8] . Nattokinase and bromelain affect clotting, and highly bioavailable curcumin has been linked to rare liver injury, so check with a physician fi...