COVID spike protein vs Vaccine spike protein: What's the Difference?
Vaccines generally work by introducing a piece of a virus or bacteria into your body so you can develop long-lasting immunity to the pathogen. While the piece introduced by the vaccine rapidly fades away, your body's immune system remembers what it saw. When it encounters the virus or bacteria in the real world it mounts a strong immune response preventing or decreasing the severity of infection.
Some have expressed concern that the spike protein or other parts of the mRNA vaccines build up in the body, particularly in the ovaries or the brain?
The spike protein is unique to SARS-CoV-2 – it doesn't look like other proteins your body makes. So antibodies created against the spike protein won't harm your body, they will only target coronavirus.
This makes sense: Lymph nodes produce white blood cells and antibodies to protect us from disease. A key part of the lymphatic system, lymph nodes also clean up fluids and remove waste materials. Finding pieces of spike protein in the lymph nodes is completely normal, because lymph nodes act as the trash removal service for the body. That means the vaccine did its job (made spike proteins, which caused the creation of antibodies) and will be cleared from the body.
Another peer-reviewed study tested exactly where an mRNA vaccine went in mice. Most of the mRNA vaccine stayed in the injection site muscle – where you get the shot. A lot of mRNA vaccine was found in local lymph nodes, which peaked about eight hours after the shot was given. A much smaller amount of mRNA vaccine went to farther away lymph nodes.
DNA is stored in the nucleus of your cells. mRNA vaccines do their work outside of the nucleus (in a space called the cytoplasm) and have not been observed to interact with the nucleus. The cell breaks down and gets rid of the mRNA soon after it's finished using the instructions.
Related: FDA Responds to Reports of DNA Contamination in COVID Vaccines
The spike protein produced by a COVID-19 mRNA vaccine is designed to mimic the spike protein found on the surface of the SARS-CoV-2 virus, the virus that causes COVID-19. While the proteins are nearly identical in their structure, the mRNA vaccine-induced spike protein is handled differently by the body. Specifically, vaccine-induced spike proteins are more likely to be stuck on the cell's outer membrane and are less likely to have escape mechanisms. This difference in how the proteins are handled leads to a reduced risk of toxicity compared to the spike proteins produced during viral infections. (source)
As I wrote in the magazine article, "The sudden appearance of a new kind of vaccine has generated concerns ranging from the spurious to the undeniable." Spike-proteins generated by the mRNA vaccines for COVID-19 -- while their lack of toxicity may not be absolute (they could in principle still bother neighboring cells, for example) -- are a good bet to be a lot less toxic than the spike proteins produced during the viral infections the vaccines prevent.
The SARS-CoV-2 Spike Protein Causes Widespread Damage...
In the study, the authors note the damaging effect the spike protein has on human cells in several organ systems:
So, We Need To Be Proactive and Remove It
The clinical rationale for the removal of spike protein is clear. It's not simply harmless pieces of viral debris.
Some have expressed concern that the spike protein or other parts of the mRNA vaccines build up in the body, particularly in the ovaries or the brain?
Why do they use spike proteins?
For COVID-19 vaccines, all of the approved vaccines so far used the spike protein. The spike protein is located on the outside of a coronavirus and is how SARS-CoV-2 (the coronavirus) enters human cells. Its location on the outside of the virus makes it so the immune system can recognize it easily.The spike protein is unique to SARS-CoV-2 – it doesn't look like other proteins your body makes. So antibodies created against the spike protein won't harm your body, they will only target coronavirus.
How long mRNA lasts in the body?
The Pfizer and Moderna vaccines work by introducing mRNA (messenger RNA) into your muscle cells. The cells make copies of the spike protein and the mRNA is quickly degraded (within a few days). The cell breaks the mRNA up into small harmless pieces. mRNA is very fragile; that's one reason why mRNA vaccines must be so carefully preserved at very low temperatures.The Infectious Disease Society of America (IDSA) estimates that the spike proteins that were generated by COVID-19 vaccines last up to a few weeks , like other proteins made by the body. The immune system quickly identifies, attacks and destroys the spike proteins because it recognizes them as not part of you. This "learning the enemy" process is how the immune system figures out how to defeat the real coronavirus. It remembers what it saw and when you are exposed to coronavirus in the future it can rapidly mount an effective immune response. The Novavax vaccine introduces the actual protein into your body to produce an immune response similar to many other vaccines currently in use.
Scientific Accuracy and Differing Views
However, updated studies claimed that the vaccine spike protein might last more than a few weeks.
- Spike Protein Persistence (709 Days): The claim that spike protein can be detected for 709 days is directly supported by the Yale study (2025). However, the study emphasizes that this was observed in a subset of PVS patients, not the general population, and the implications of this persistence are unclear.
- The study titled, Altered Circulating Cytokine Profile Among mRNA‐Vaccinated Young Adults: A Year‐Long Follow‐Up Study, was published in the journal Immunity, Inflammation and Disease (April 2025): "this study found that in young adults (mean age = 27.2), mRNA injection likely leads to sustained Spike protein production lasting at least one year—evidenced by persistently elevated levels of multiple proinflammatory cytokines. Elevation of inflammatory markers is likely to play a role in symptomatic long pandemic syndromes."
- A study of 19 stroke victims published in the Journal of Clinical Neuroscience (2025) confirmed that spike protein from mRNA COVID-19 vaccines can remain in the cerebral arteries for up to 17 months. In one case, a 70-year-old woman, had spike protein present 17 months after her last shot and in another, 11 months. None of the cases showed nucleocapsid protein positivity, supporting the absence of active viral infection.
- Another study published in Molecular Systems Biology (2025) revealed that mRNA vaccines induce a highly dynamic and persistent training of innate immune cells enabling a sustained pro-inflammatory immune response. According to Sonia Elijah, "The findings point to a disturbing picture of chronic inflammation with cancer risks (e.g., Roe et al., 2017, on H3K27ac in leukemia) tied to this epigenetic rewiring."
Where does the vaccine go?
Here's a peer-reviewed study that shows where intramuscular vaccines (which all three of the COVID-19 vaccines are) travel in macaques (a type of monkey). Vaccines mostly remain near the site of injection (the arm muscle) and local lymph nodes.This makes sense: Lymph nodes produce white blood cells and antibodies to protect us from disease. A key part of the lymphatic system, lymph nodes also clean up fluids and remove waste materials. Finding pieces of spike protein in the lymph nodes is completely normal, because lymph nodes act as the trash removal service for the body. That means the vaccine did its job (made spike proteins, which caused the creation of antibodies) and will be cleared from the body.
Another peer-reviewed study tested exactly where an mRNA vaccine went in mice. Most of the mRNA vaccine stayed in the injection site muscle – where you get the shot. A lot of mRNA vaccine was found in local lymph nodes, which peaked about eight hours after the shot was given. A much smaller amount of mRNA vaccine went to farther away lymph nodes.
Can the COVID-19 vaccines change your DNA?
No. COVID-19 vaccines cannot change your DNA.DNA is stored in the nucleus of your cells. mRNA vaccines do their work outside of the nucleus (in a space called the cytoplasm) and have not been observed to interact with the nucleus. The cell breaks down and gets rid of the mRNA soon after it's finished using the instructions.
Related: FDA Responds to Reports of DNA Contamination in COVID Vaccines
Vaccine spike protein differs from COVID spike protein
According to Google AI Overview:
Billions of doses of the mRNA vaccine targeting SARS-CoV-2, the virus that causes COVID-19, have been given worldwide, unquestionably saving many lives. But the molecular delivery vehicles now used to transport mRNA to the right places in the body sometimes deliver it to the wrong places, or hold on to that cargo rather than letting it go once they get inside our cells. (Stanford University researchers are working on new delivery systems.)
Inside a SARS-CoV-2-infected cell, the virus commandeers the cell's protein-making machinery and forces it to make myriad copies of the invader's own proteins and genetic material. Once made, the vast majority of newborn spike proteins are incorporated into new viral particles that have evolved ingenious ways of escaping from the cell that made them. Those particles are free to invade the cell next door or spill into the circulatory system and points beyond.
Some of those virally originating spike protein molecules miss their exit bus and wind up getting stuck on the cell's outer membrane. That's how the immune system learns to attack SARS-CoV-2-infected cells directly as well as to start pumping out antibodies that put the little pathogens out of business before they can get into more cells, Davis said.
According to Prof Peter Kim:
But what about the cargo itself - mRNA strands in the vaccine? More specifically, what about the protein that this cargo instructs our cells to make in profusion? In the case of COVID-19, that would be the infamous spike protein, which dots SARS-CoV-2's coat, picks locks on cells' outer surfaces and catapults the virus into them.
These multiple talents make the spike protein essential to the virus's ability to infect our cells. This, plus the fact that spike proteins jut prominently and abundantly from the virus's coat, makes the spike protein the perfect object for our immune system to target and attack, said Stanford Institute for Immunology, Transplantation and Infection director Mark Davis, PhD, an authority on immune response.
A toxic possibility
It’s important to understand that 320 peer-reviewed scientific studies demonstrate that the Spike protein is highly pathogenic on its own and causes damage to all organ systems while persisting in the body for years. Thus, it can be reasonably assumed that clearing the body of this potent toxin is a key step toward addressing post-vaccination syndromes and long-COVID.Contact with the spike protein appears to damage endothelial cells, which line every blood vessel in our body, including hundreds of billions in our lungs. If spike proteins are toxic, wouldn't a vaccine that causes our cells to make them be toxic, too?Could the mRNA vaccines directed at SARS-CoV-2 trigger a deluge of that protein into the bloodstream, where it could wreak havoc with heavily vascularized organs such as the heart, intestine and, of course, lungs?
Conversations with several Stanford Medicine experts suggest there may be less to this concern than meets the eye. Here's one reason: For virtually every spike-protein molecule induced by vaccination, the cell that made it becomes its jail cell.
Many proteins our cells make also have transmembrane domains. Why? Because these patches anchor protein molecules in the cell's fat-rich outer membrane or in one of its myriad equally fat-laden internal membranes, as required by these proteins' jobs.
The sticky transmembrane domain on SARS-CoV-2's spike protein plays two roles. First, it rivets the protein to the intact virus's fatty outer coat. Second, it catalyzes penetration of cells the virus is attempting to invade.
Inside a SARS-CoV-2-infected cell, the virus commandeers the cell's protein-making machinery and forces it to make myriad copies of the invader's own proteins and genetic material. Once made, the vast majority of newborn spike proteins are incorporated into new viral particles that have evolved ingenious ways of escaping from the cell that made them. Those particles are free to invade the cell next door or spill into the circulatory system and points beyond.
Some of those virally originating spike protein molecules miss their exit bus and wind up getting stuck on the cell's outer membrane. That's how the immune system learns to attack SARS-CoV-2-infected cells directly as well as to start pumping out antibodies that put the little pathogens out of business before they can get into more cells, Davis said.
Spike protein molecules induced by mRNA vaccines have a different fate.
Recall that the COVID-19 vaccine's cargo is a bunch of mRNA strands that, once safely inside a cell, direct the production of a whole lot of a single substance: the spike protein. Once produced inside a vaccine-recipient cell, it has no escape accomplices (the other components of the viral structure) to latch onto, because the cell isn't making them. So, it has no dependable passage out of the cell. Instead, Davis told me, the vast majority of vaccine-induced spike proteins float or are carried, either intact or sawed into snippets by enzymes inside the cell, to the cell's outer membrane. There they get stuck, right where the immune system can most easily spot them and mount a coordinated response.
"An intact vaccine-generated spike protein molecule, by virtue of its transmembrane domain, almost invariably sticks to the cell that makes it," agreed vaccinologist and biochemistry professor Peter Kim, PhD.
According to Prof Peter Kim:
As I wrote in the magazine article, "The sudden appearance of a new kind of vaccine has generated concerns ranging from the spurious to the undeniable." Spike-proteins generated by the mRNA vaccines for COVID-19 -- while their lack of toxicity may not be absolute (they could in principle still bother neighboring cells, for example) -- are a good bet to be a lot less toxic than the spike proteins produced during the viral infections the vaccines prevent.
The Science of Spike Protein Removal
Thanks in part to the work of renowned cardiologist (and outspoken COVID-regime critic) Peter McCullough, we now have a robust look at all the medications & supplements with the power to bind, remove, dissolve, and disrupt the spike protein.
If you're looking for the study, here it is: McCullough Spike Study. The study is scientific, but not oppressively so. I'd encourage everybody to take a look and read it, but I'll also summarize the key findings here.
If you're looking for the study, here it is: McCullough Spike Study. The study is scientific, but not oppressively so. I'd encourage everybody to take a look and read it, but I'll also summarize the key findings here.
The SARS-CoV-2 Spike Protein Causes Widespread Damage...
In the study, the authors note the damaging effect the spike protein has on human cells in several organ systems:
 |
| The many mechanisms of action involved in the ultimate removal of spike protein. |
- Cardiovascular System
- Hematological System
- Neurological System
- Respiratory System
- Gastrointestinal System
- Immunological System
- From the virus itself, and;
- From the COVID-19 vaccines.
So, We Need To Be Proactive and Remove It
The clinical rationale for the removal of spike protein is clear. It's not simply harmless pieces of viral debris.
Conclusion and Recommendations
If you’re concerned about PVS or vaccine side effects, consult a healthcare provider. The scientific community is still learning about PVS, and more research is needed to understand its causes and potential treatments.As with many conflicting recommendations, it's best to consult your trusted healthcare provider and carefully weigh the potential benefits against the possible risks before making a decision.
Sources and References:
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