Formerly The COVID Advisor — evidence-based analysis of Long COVID, immune injury, and post-viral disease
Dr Peter McCullough: Practical Prevention and Management of Viral Upper Respiratory Tract Infections
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Editorial Team
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Please enjoy this practical segment on Real America’s Voice American Sunrise concerning the prevention of viral upper respiratory tract infections from rhinovirus to bird flu. Dr. Gina Loudon like so many of us is routinely using nasal and throat sprays to prevent catching colds from airplanes and contacts in everyday life.
*According to Dr Peter McCullough (X/Twitter):"ImmuneMist nasal and throat sprays twice a day provides basis for adequate protection of farm workers against seasonal and avian influenza. Contagion kits provide early antiviral therapy and antibiotics if needed for secondary infection."
Of interest, she took aim at the adverse effect of sugary drinks like Gatorade on infection-related inflammation preferring tea with honey for her sick kids. I upgraded her idea with manuka honey which has been found to have antiviral activity as demonstrated by Watanabe et al.
Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N. Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey. Arch Med Res. 2014 Jul;45(5):359-65. doi: 10.1016/j.arcmed.2014.05.006. Epub 2014 May 29. Erratum in: Arch Med Res. 2014 Aug;45(6):516. PMID: 24880005.
It is our hope that these quick health updates are useful serving as reminders to be prepared with medical emergency kits from The Wellness Company. With the holidays upon us, our collective aim is to stay well and free from the misery of common upper respiratory infections.
Base Spike Detox According to Dr Peter McCullough (in a X/Twitter post): Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. I have arrived, based on the emerging scientific literature (1) and my clinical observation, that three OTC products are essential as a triple base combination: Nattokinase 2000 FU (100 mg) twice a day — take on an empty stomach Bromelain 500 mg once a day — take on an empty stomach Nano/Liposomal Curcumin 500 mg twice a day — take with food How long should I take this? Dr. McCullough recommends a minimum of 3 months , with many patients requiring 6–12 months or longer. Progress can be tracked via a spike protein antibody test (available through Labcorp in m...
An evidence-tiered review of the nattokinase, bromelain and curcumin regimen proposed by Dr. Peter McCullough: what it is, what the research does and does not show, how to use it safely, and how (not) to monitor it. By OneDayMD Editorial Team | Originally published March 2026 | Last updated October 18, 2026 | Sources reviewed through October 18, 2026 | Next scheduled review: April 2027 Quick answer The McCullough Base Spike Detox is a clinician-proposed regimen of nattokinase (2,000 FU twice daily), bromelain (500 mg daily) and nano/liposomal curcumin (500 mg twice daily) intended to break down persistent SARS-CoV-2 spike protein. [1] Laboratory studies show nattokinase can degrade spike protein in cell and test-tube systems TIER 3 [2] [3] , and spike antigen does persist in a minority of people for months after infection TIER 2 [8] . Nattokinase and bromelain affect clotting, and highly bioavailable curcumin has been linked to rare liver injury, so check with a physicia...
Dr. McCullough explained (1) that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. Spike Protein Protocol Personalizer Based on Dr. Peter McCullough's Base Spike Detox & FLCCC I-Recover Frameworks ⚠ Medical Disclaimer: This tool is...
By OneDayMD Editorial Team · Published September 30, 2026 · Updated October 2026 Quick Answer: does anything work for Long COVID? No specific treatment has been proven to work for Long COVID in general. Randomized trials have found no benefit from extended Paxlovid (959 adults), metformin (396) or short-course hyperbaric oxygen (80). Promising but unconfirmed signals include the SIM01 synbiotic (463 people, Hong Kong), physical-activity coaching (50) and the Ultimate Spike Detox. For prevention during acute COVID, Paxlovid (144 people) and metformin show mixed or underpowered results. Care remains individualized and symptom-focused. Medical disclaimer. This article is educational and is not personal medical advice, diagnosis or treatment. Long COVID can overlap with cardiovascular, pulmonary, neurological, endocrine and sleep disorders. Do not start, stop or change pres...
By OneDayMD Editorial Team | Originally published May 2023 | Last updated October 2026 | Sources reviewed through October 2026 Quick Answer The FLCCC/IMA I-CARE Flu and RSV protocol is a home regimen of nasal and mouth antiseptics, supplements and off-label drugs. Most components are supported by laboratory or expert-opinion evidence, not influenza trials. The best-evidenced treatments for influenza are prescription antivirals started early: oseltamivir for hospitalized patients and baloxavir or oseltamivir for high-risk outpatients. Seek care promptly if you are high-risk or struggling to breathe. What changed in this update (October 2026) Fixed copy-paste wording that described the protocol as a COVID-19 guide. Replaced the claim that Tamiflu has “no antiviral properties.” Oseltamivir is a direct-acting neuraminidase inhibitor, and the 2025 paper is in JAMA Ne...
Medically reviewed by: OneDayMD Editorial Team | Last updated: August 2026 Introduction The rapid development and deployment of COVID-19 vaccines have been monumental in combating the global pandemic, saving countless lives and enabling societies to regain a sense of normalcy. Central to the efficacy of many of these vaccines, particularly mRNA and viral vector-based ones, is the spike protein—a key component of the SARS-CoV-2 virus that facilitates its entry into human cells. By instructing the body to produce a version of this protein, vaccines train the immune system to recognize and neutralize the virus without causing illness. However, as vaccination campaigns expanded, so did public curiosity and concern about the spike protein's role, fueled by a mix of scientific complexity, misinformation, and distrust. For years, the public was told that COVID-19 mRNA vaccine components degraded rapidly—within days to weeks. Hulscher, McCullough, and colleagues' ...
A laboratory worker at an anti-plague research institute in Siberia died after developing severe pneumonia. Russian authorities have not confirmed plague , while conflicting reports have fueled concern about a possible pneumonic-plague infection or laboratory exposure. Updated: October 6, 2026 | Status: Developing story Important: There is no confirmed evidence, as of October 6, 2026, that a pneumonic-plague outbreak is occurring in Siberia. Russia's federal public-health watchdog, Rospotrebnadzor, has described the patient's illness as pneumonia of unknown etiology and said expanded testing did not identify microorganisms associated with her professional activity. The World Health Organization has said that, based on available information, the public-health risk to the general population appears low. What happened in Irkutsk? A 28-year-old employee identified by local and international reporting as Da...
Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough Protocol 2022 Update: Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial ( JAMA 2025 ) Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the prior strains of the virus. Thus, there is a wonderful opportunity to reduce viral replication, in fa...
Immune Systems Advisor · Integrative Medicine White Paper · Open Access Authors: OneDayMD Editorial Team (synthesis and editorial adaptation) · Original protocols: Marik P, Kory P (IMA/FLCCC, 2022–2024); McCullough PA (Cureus, 2023) · Published: March 2023 · Last updated: July 2026 Evidence Tier Key: TIER 1 RCT / systematic review TIER 2 Observational / cohort TIER 3 In vitro / mechanistic TIER 4 Expert consensus / clinical observation ⚠ Medical Disclaimer — Please Read First. This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The protocols described involve supplements with significant anticoagulant activity. Always consult a licensed physician before starting, especially if you take blood thinners, are pregnant or breastfeeding, have a bleeding disorder, or are treating a child. For a virtual con...
Medical Disclaimer: This directory is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or prescription medication. Directory: Find Early Outpatient COVID-19 Telemedicine Doctors & Prescribers Treatment decisions should be made in consultation with a licensed healthcare professional based on clinical evaluation as early as possible after symptom onset. Below is an updated directory of licensed physicians, clinics, and nationwide telemedicine providers offering outpatient consultations, early treatment evaluations, and custom health protocols. Related: How to Get Ivermectin in the US : Pharmacies, Legal Status & State-by-State Access (2026) Multi-State & Nationwide Telemedicine Services The following medical organizations and licensed practices offer virtual healthcare consultations across multiple states: ...
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