FLCCC I-Recover Protocol: COVID Long Haulers Treatment Protocol
The FLCCC (Front Line COVID-19 Critical Care Alliance) was formed by leading critical care specialists in March 2020, at the beginning of the Coronavirus pandemic, dedicated to developing highly effective treatment protocols to prevent the transmission of COVID-19 and to improve the outcomes for patients ill with the disease.
Patients with post-vaccine syndrome should do whatever they can to prevent themselves from getting COVID-19. This may include a preventative protocol (see I-PREVENT) or early treatment in the event you do contract the virus or suspect infection (see I-CARE). COVID-19 will likely exacerbate the symptoms of vaccine injury.
Once a patient has shown improvement, the various interventions should be reduced or stopped one at a time. A less intensive maintenance approach is then suggested.
The core problem in post-vaccine syndrome is long-lasting “immune dysregulation.” The most important treatment goal is to help the body restore a healthy immune system — in other words, to let the body heal itself. Our recommended treatment strategy involves two major approaches:
- Promote autophagy to help rid the cells of the spike protein
- Use interventions that limit the toxicity/pathogenicity of the spike protein
As noted previously, the major difference between long COVID and long vax is unresolved organizing pneumonia with persistent respiratory symptoms. Therefore, in patients with ongoing respiratory symptoms, chest imaging is suggested (preferably a chest CT scan). (R)
Those with unresolved pulmonary inflammation (organizing pneumonia with ground glass opacification) should be treated with a course of corticosteroids. Low-dose prednisolone/methylprednisolone (10 mg/day) for six weeks is suggested. However, the patient’s symptoms and CRP should be followed closely, as a dose escalation may be required in those who respond poorly.
An unknown number of patients who have recovered from COVID-19 organizing pneumonia will develop pulmonary fibrosis with associated limitation of activity. Pulmonary function testing demonstrates a restrictive type pattern with decreased residual volume and DLCO. These patients should be referred to a pulmonologist with expertise in pulmonary fibrosis. Anti-fibrotic therapy may have a role in these patients, however additional data is required before this therapy can be more generally recommended. The serotonin receptor blocker cyproheptadine may reduce the risk of pulmonary fibrosis.
Diagnostic Tests for Long COVID
This protocol is solely for educational purposes regarding potentially beneficial therapies for COVID-19. Never disregard professional medical advice because of something you have read on our website and releases. This protocol is not intended to be a substitute for professional medical advice, diagnosis, or treatment with regard to any patient. Treatment for an individual patient should rely on the judgement of a physician or other qualified health provider. Always seek their advice with any questions you may have regarding your health or medical condition. Please note the FLCCC full disclaimer at: www.flccc.net/disclaimer
Be on the Lookout for Blood Clots for 90 DaysIf you’ve had COVID-19, especially if it was a severe case, be aware that blood clots and heart problems, including heart attack, can occur for 90 days or more. It’s believed that remnants of the virus remain in the nervous system, the lungs, the heart and other organs.
If the symptoms include major shortness of breath, cough with blood in it or pain on one side when you take a deep breath, it could be due to a late pulmonary embolism or a blood clot going to the lungs. “We’ve seen this on more than one occasion,” Dr Peter McCullough said.
Aside from a CT scan to rule out pulmonary embolism if you’re having symptoms and possibly a D-dimer test, McCullough suggests a high-sensitivity C-reactive protein (CRP) test, which provides a general index of inflammation. Keep in mind, though, as McCullough said:
“This pursuit of a blood clot is very important. I’ve seen multiple cases now where blood clots have been missed … this is now almost a daily occurrence, particularly within the first 90 days after COVID-19. I think after that period of time it becomes progressively less likely.”
Diet and Nutrition
It is believed that eating fruits, vegetables, and getting physical exercise is beneficial to thrombotic status—especially in those who are at risk of thrombotic diseases.
In many countries including the United States, recommendation for an antithrombotic diet and adequate physical exercise have been proposed by health authorities.
Supporting a good nutrient baseline is also key. “We see a significant amount of nutrient deficiencies and insufficiencies in the United States,” Boham says. Notably, insufficient levels of zinc and selenium are associated with worse outcomes from viral infections. Good sources of zinc include oysters, hemp seeds and pumpkinseeds, beans, nuts, and animal protein; sources of selenium include mushrooms, Brazil nuts, and seafood.
“Make sure you’re getting eight to 12 servings of phytonutrients a day from vegetables, fruits, spices, herbs, and tea,” she advises. Phytonutrients such as EGCG (epigallocatechin gallate, a polyphenol found in green tea) and curcumin (found in turmeric) can decrease inflammation and rebalance the immune system.
Antithrombotic Therapy (Ref)In general, there are two classes of antithrombotic drugs: anticoagulants and antiplatelet drugs. Anticoagulants act on the clotting cascade and keep it from completion while antiplatelet medicines inhibit the platelets from activating and attaching to each other and the endothelium.
Dr. Jordan Vaughn, internal medicine specialist in Birmingham, Alabama, says it’s key to start antithrombotic treatment in affected patients as early as possible.
“In the acutely ill from COVID-19, it was the sickest that I put on anticoagulation to prevent them from hospitalization. Starting them on DOAC and antiplatelet therapy was the foundation of keeping the hypoxic COVID-19 patient requiring hospitalization,” Dr. Vaughn said.
“After reading and understanding the COVID-19 associated coagulopathy, it was critical to understand this pathophysiology and manage this unique disease state because all of them are hypercoagulable. In acute severe COVID, I would treat patients with antithrombotic therapy and have them come back every few days to see if their symptoms improve.”
“In those that I would start anticoagulation, I started to notice that not only did they get better, but very few of them came back with long-term complications. So it seemed to me that, theoretically, it was like whatever we’re doing differently and treating these patients that are typically sicker was actually improving their symptoms in acute phase and also for the most part prevented the post-acute sequela that often came later in patients that were never acutely severe.”
Dr. Vaughn said he selects some coagulation lab tests to see if his patients were elevated in those factors at all.
“It was after the success of antiplatelet and anticoagulation in the acute treatment of COVID that I started to wonder about utilizing it in post acute sequelae COVID (PASC), and was led by diligent research to the work of Jaco Laubscher, Resia Pretorious, and Doug Kell.”
“It was as if a light bulb went off when I read their work. It profoundly changed how I look at both acute covid, but most importantly long COVID/PASC and their work was instrumental to truly helping suffering patients.”
Whether the cause of blood clots is the virus or vaccine, the symptoms do not differ much because the foundational cause is the spike protein.
Thus, when treating syndromes involving microclotting and local tissue hypoxia, regardless of the source of spike protein, the mess to clean up is the same.
It has been also reported that suitable and closely monitored “triple” anticoagulant therapy leads to the removal of the microclots and also removes symptoms.
It is a dual antiplatelet therapy (DAPT) (Ciopidogrel 75 mg and Aspirin 75 mg) once a day and direct oral anticoagulant (DOAC) (Apixiban 5 mg twice a day). In addition, it is important to include stomach protection with a medicine like a h2 blocker or a proton pump inhibitor.
At this point, the length of treatment is unknown and usually relies on a careful history of the patient’s interactions with the spike protein, time since last exposure, history of underlying autoimmune dysfunction, and overall functional symptomatology.
Dr. Vaughn’s treatments are driven by these factors, and typically lasts from one to three months. His hope is for a robust clinical trial soon to further inform length and identify additional surrogate clinical markers for clinicians to use to identify patients that would benefit from treatment.
Nutraceuticals for Thrombotic Conditions (Ref)There are a variety of dietary supplements that may have a beneficial effect for thrombotic conditions (R).
Meanwhile, many of these compounds also have anti-inflammatory, anti-oxidative, and autophagy-boosting effects which are beneficial for COVID-related symptoms as well.
Resveratrol has antiplatelet properties. It is a naturally occurring flavonoid primarily found in grapes, red wine, and peanuts.
A dose-dependent inhibitory effect of resveratrol on platelet aggregation has been observed in cellular and animal models.
Furthermore, resveratrol’s multiple effects of lowering of oxidative stress and inflammation, enhancing metabolic capacity, increasing nitric oxide synthesis by endothelial cells, and promoting autophagy are beneficial for patients with COVID related clotting issues as well.
A major component in green tea, epigallocatechin-3 gallate (EGCG) is believed to actively inhibit platelets in humans. EGCG targets multiple pathways to achieve this role.
Genistein, a tyrosine kinase inhibitor, is an inhibitor of platelet aggregation and has effects in preventing thrombotic occlusion in blood vessels. It is found predominantly in soy products.
Genistein’s primary mechanism at least includes to inhibit platelet aggregation induced by collagen,; and antagonistic effects for thromboxane receptors.
The compounds of adenosine, allicin, and paraffinic polysulfides appear to be responsible for the inhibitory effect of garlic on platelet aggregation.
Derived from the cleavage of alliin by alliin lyase, allicin inhibits platelet activity in vitro without affecting cyclooxygenase, lipoxygenase, thromboxane, vascular prostacyclin synthase, or cyclic AMP levels.
Well known for its antioxidant function, vitamin E has multiple beneficial properties for clotting conditions.
For example, it improves the activity of endothelium-derived nitric oxide, improves endothelial function in part due to the inhibition of protein kinase C (PKC), and inhibits platelet aggregation.
Vitamin E has been shown to decrease platelet adhesion to collagen, fibrinogen, and fibronectin, and increase platelet sensitivity to prostaglandin E1.
Selenium is a trace element and an essential component of glutathione peroxidase enzymes, protecting cells from oxidative stress. A deficiency in selenium is associated with an increased risk of arterial thrombosis.
Selenium has an effect of inhibiting platelet aggregation, primarily through inhibiting those substances forming blood clots.
The impact of dietary supplements on normal hemostasis and antithrombotic therapy should be given consideration.
Supplements that have been reported to affect normal coagulation and platelet activity and/or have been reported to possibly interact with coumarin anticoagulants include danshen, garlic , ginkgo, American ginseng, Asian ginseng.
However, most of these reports are either theoretical or consist of individual cases.
Fasting also supports the turnover of damaged cells throughout the body, making room for new, healthy mitochondria and cells to take their place.
Time-restricted eating can take a variety of forms. One of the most popular is simply eating all your day’s meals within an eight-hour window, then going 16 hours without food or calories.
Exercise could help moderate the effects of Long COVID
COVID Jab Injuries Treatment for Kids
“If you're making spike [protein], even though kids don't have a lot of ACE2 receptors, those spikes are everywhere. In mice, it is shown that they cross the blood-brain barrier. They're disseminated, and then they tend to focus in your area of weakness.
They go into fat-loving tissues, they go into the ovaries, they seem to go everywhere. So, binding the spike protein, that's one aspect, and there are different things you can do, both pharmaceutical and non-pharmaceutical.
My favorite is ivermectin for the spike. I was giving kids 12 milligrams, initially, once a day. I went up to 12 mg twice a day for Omicron, but it depends on the size of the kid. For bigger kids, it’s 18 mg twice a day.
I didn't see any toxicity with ivermectin. I've used ivermectin before, mostly for parasitic infections, and I never had any problem with ivermectin. I have not used hydroxychloroquine before, but now, for Omicron, I would use hydroxychloroquine, 200 mg twice a day.
I use a lot of quercetin and zinc together ... To decrease inflammation, especially IL6, you also want to use a lot of immunomodulators, and a lot of supplements can do that.”
- Find a Provider Directory
- List of Pharmacies that will fill Ivermectin
- www.ifm.org/find-a-practitioner (Functional Medicine)
- Post-COVID Care Centers (PCCC) by Survivor Corps
Your immune system can be weakened by over 300 different primary immunodeficiency disorders, poor diet, lack of sleep, and adverse reactions to various vaccines.
That’s where Z-DTOX comes in! Z-Dtox is Dr. Zelenko’s proprietary combination of NAC, EGCG, Zinc, Vitamin C, and Vitamin D.
- Epigallocatechin gallate (EGCG) is an extract of green tea and is a powerful zinc Ionophore (zinc delivery system).
- N-acetyl cysteine (NAC) is a supplement form of cysteine. It may prevent blood clots and is an antioxidant.
- Zinc is critical for immune cell development. Dozens of different enzymes in the body rely on zinc.
- Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters.
- Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and many other biological effects.
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- This post is not medical advice. This post is for informational and educational purposes only.
- Always see or talk to your doctor before taking these drugs, supplements and over the counter products. Be aware that most of the 'treatment' dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis.
- Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19.
- You still need to follow the advice given by CDC, WHO and your local authority in terms of local guidelines such as mask wearing, social distancing, vaccination and avoiding crowds. It's better to combine multiple strategies in order to defend yourself against this virus.
- According to US NIH: "...Guidelines should not be considered mandates. The choice of what to do or not to do for an individual patient is ultimately decided by the patient and their provider."