Holy Grail of COVID-19 Spike Protein Detoxification
This would be an advantage for a normal human protein being replaced in a rare genetic deficiency state (e.g., alpha galactosidase in Fabry’s disease). However, it is a big problem when the protein is the pathogenic SARS-CoV-2 spike. The adenoviral DNA (Janssen) should be broken down by deoxyribonuclease, however, this has not been exhaustively studied.
This leaves dissolution of spike protein as a therapeutic goal for the vaccine injured. With the respiratory infection, spike is processed and activated by cellular proteases including transmembrane serine protein 2, cathepsin, and furin. With vaccination, these systems may be avoided by systemic administration and production of spike protein within cells. As a result, the pathogenesis of vaccine injury syndromes is believed to be driven by accumulation of spike protein in cells, tissues, and organs.
Nattokinase is an enzyme is produced by fermenting soybeans with the bacteria Bacillus subtilis var. natto and has been available as an oral supplement. It degrades fibrinogen, factor VII, cytokines, and factor VIII and has been studied for its cardiovascular benefits. Out of all the available therapies I have used in my practice and among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.
Tanikawa et al. examined the effect of nattokinase on the spike protein of SARS-CoV-2. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.
Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2000 FU D-dimer concentrations at six, and eight hours, and blood fibrin/fibrinogen degradation products at four hours after administration elevated significantly (p < 0.05, respectively).
Thus an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs.
Based on these findings, nattokinase and similar products such as serrapeptase should undergo well-funded, accelerated preclinical and clinical development programs. The issue at hand is the urgency of time, similar to that with SARS-CoV-2 infection and empiric early therapy. It will take up to 20 years to have a fully developed pharmaceutical profile to characterize the safety and efficacy of nattokinase in the treatment of vaccine injury and post-COVID syndromes.
Large numbers of people are sick now and many believe empiric treatment is justified given the sufficiently low risk of side effects and potentially high reward. My recommendation is to discuss this with your doctor or seek a specialist in holistic or naturopathic medicine who is experienced with the safety profile of nattokinase in a range of applications.
Reposted from Peter A. McCullough’s Substack
Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.
Oba M, Rongduo W, Saito A, Okabayashi T, Yokota T, Yasuoka J, Sato Y, Nishifuji K, Wake H, Nibu Y, Mizutani T. Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro. Biochem Biophys Res Commun. 2021 Sep 17;570:21-25. doi: 10.1016/j.bbrc.2021.07.034. Epub 2021 Jul 13. PMID: 34271432; PMCID: PMC8276596.
Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.
Cancer and Spike Protein: What's the Link?
Final ThoughtsAlthough the research on nattokinase and its effect on COVID-19 is still in its infancy, the ability of nattokinase to degrade spike proteins combined with its anti-clotting properties makes it an exciting topic for further study.
Some researchers and clinicians theorize that symptoms of long COVID may be at least partially due to the blockage of vessels by microclots, and that the spike protein might be the trigger—which is supported by a recent Harvard Medical School study. If this is the case, nattokinase could be a potential treatment for those suffering from long COVID and its extensive list of symptoms.
Nattokinase’s anti-clotting prowess and ability to dissolve spike proteins could also be helpful with the clotting problems many doctors have observed in those who took the vaccine, and could be a way to dissolve those blood clots before they can do irreparable damage to tissues and organs.
Researchers will be studying nattokinase in a lab setting to help find the answers, but these initial findings suggest that this humble Japanese dish may hold the key to unlocking some of the most critical health obstacles we face. At the very least, it’s a nutritious food that boosts the microbiome.
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