Independent COVID-19 Guides, Resources and Protocols - Reducing Risk of COVID-19 Infection and Severity
Dr Peter McCullough: Does Nattokinase Dissolve Spike Protein?
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By
Dr Frank Yap, M.D.
-
Far and away the most common question I get from those who took one of the
COVID-19 vaccines is: “How do I get this out of my body.” The mRNA and
adenoviral DNA products were rolled out with no idea of how or when the body
would ever break down the genetic code. The synthetic mRNA carried on lipid
nanoparticles appears to be resistant to breakdown by human ribonucleases by
design so the product would be long-lasting and produce the protein product of
interest for a considerable time period.
This would be an advantage for a normal human protein being replaced in a rare
genetic deficiency state (e.g., alpha galactosidase in Fabry’s disease).
However, it is a big problem when the protein is the pathogenic SARS-CoV-2
spike. The adenoviral DNA (Janssen) should be broken down by deoxyribonuclease,
however, this has not been exhaustively studied.
This leaves dissolution of spike protein as a therapeutic goal for the vaccine
injured. With the respiratory infection, spike is processed and activated by
cellular proteases including transmembrane serine protein 2, cathepsin, and
furin. With vaccination, these systems may be avoided by systemic administration
and production of spike protein within cells. As a result, the pathogenesis of
vaccine injury syndromes is believed to be driven by accumulation of spike
protein in cells, tissues, and organs.
Base Spike Detox
According to Dr Peter McCullough (in a Twitter post - July 2023):
Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. A major publication is under review and editing; however, the information is far too important to hold back.
Update (Nov 2023): Published on August 25, 2023 in Journal of American Physicians and Surgeons. CLICK HERE FOR THE COMPLETE PAPER > Base Spike Protein Detoxification and on November 21, 2023 in Cureus (PubMed - November 2023)
I have arrived, based on the emerging scientific literature and my clinical observation, that three OTC products are essential as a triple base combination:
Nattokinase 2000 FU (100 mg) twice a day
Bromelain 500 mg once a day
Nano/Liposomal Curcumin 500 mg twice a day
Additional products can be added, including NAC, IVM (Ivermectin), HCQ (Hydroxychloroquine), fluvoxamine, low-dose naltrexone, and blood thinners, depending on the clinical evaluation and the syndrome. The therapeutic objective is to start treatment and allow the body to clear Spike and its fragments with the natural reticuloendothelial system. I believe this triple combination is the best approach.
Patients can get a big head start if they self-initiate Base Spike Detox as they get organized for appointments. I have found three months is a minimum duration, and some require more than a year. Don’t expect instant results, be patient. I have a major manuscript under review for publication that summarizes the clinical rationale and evidence supporting Base Spike Detox.
Important safety warnings include bleeding for those on blood thinners or who have bleeding disorders (e.g., hemophilia), soy allergy, allergies to any component of the combination, and gastrointestinal intolerance. Women of childbearing potential without contraception, pregnant, breastfeeding, and children should not take this combination unless directed by a doctor.
Nattokinase and Spike Protein
Nattokinase is an enzyme is produced by fermenting soybeans with the bacteria Bacillus subtilis var. natto and has been available as an oral supplement. It degrades fibrinogen, factor VII, cytokines, and factor VIII and has been studied for its cardiovascular benefits. Out of all the available therapies I have used in my practice and among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.
Tanikawa et al. examined the effect of nattokinase on the spike protein of SARS-CoV-2. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.
Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2000 FU D-dimer concentrations at six, and eight hours, and blood fibrin/fibrinogen degradation products at four hours after administration elevated significantly (p < 0.05, respectively).
Thus an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs.
Editor's Note: We are aware of a fact-check article by AFP titled "Experts rubbish Covid vaccine 'detoxification' supplement". In my humble opinion, the title may come across as excessively confident and strongly worded.
The article makes a claim that 'There is no evidence that nattokinase dissolves the spike protein of SARS-CoV-2 in the human body,' while also citing evidence from the Tanikawa study. It's important to acknowledge that the Tanikawa study is a small lab study, which is a common starting point in the research process before moving on to larger studies.
Nevertheless, we agree that nattokinase is not a miracle drug, and further research is necessary. It's worth noting that there are more than 200 studies related to nattokinase published on PubMed.
Moreover, it's essential to recognize that there are multiple approaches to managing COVID-19. We encourage you to consult with your trusted healthcare provider to thoroughly discuss and assess the potential benefits and risks of various possible treatments.
Ivermectin and Spike Protein
Former NIH researcher David Scheim, PhD, early in the pandemic proposed that SARS-CoV-2 Spike protein was acting like a grappling hook pulling together circulating red blood cells (RBCs) into long chains and clumps in a process called hemagglutination (HA).
This explained why the red blood cells could not carry oxygen normally and was congruent with the finding of micro blood clots in the lungs. Boschi et al have provided additional support for this mechanism (source). By reversing the clumping of red blood cells, ivermectin enabled the patient’s proper respiratory function to return.
According to the authors:
“Ivermectin blocked HemAgglutination when added to RBCs prior to spike protein and reversed HA when added afterwards.”
In another spectacular publication, Stone et al, describes the prompt improvement of oxygenation in patients with ivermectin (source).
The published oxygenation curves from multiple studies clearly show this physiological effect of ivermectin occurs so rapidly, it must be explained by a direct anti-Spike protein effect of ivermectin. An anonymous video of a critically ill man demonstrates the very effect that Scheim, Stone, Hazan, and Babalola have described in the Figure above. So for the next critically ill patient with COVID-19, if the opportunity presents itself, push for the administration of ivermectin. This is the only published therapy for COVID-19 that improves oxygen saturation while the patient mounts a recovery. As in this man, it may be the critical factor for a turnaround and a chance to walk out of the hospital.
Editor's Note:
Why should you trust this article? While we don't ask for blind trust, we do encourage you to trust in your own judgment. Our primary goal is to empower you to conduct thorough research and make informed healthcare decisions in consultation with your trusted medical doctor.
Though there are many spike protein detox treatment protocols out there, we consider and recommend the I-Recover protocol as one of the best.
Given the lack of clinical trials of long-haul COVID-19 syndrome, these recommendations are based on the abnormal changes within the body associated with the COVID-19 disease and post viral illnesses along with the collective experience of FLCCC members.
This protocol has also been used to treat post-vaccine inflammatory syndromes with similar success. As with all FLCCC Alliance protocols, the components, doses, and durations will evolve as more clinical data accumulates.
Due to the marked overlap between long COVID and post-vaccine syndrome, please refer to the I-RECOVER Post-Vaccine Treatment protocol for detailed treatment strategies.
Does spike protein stay in body forever?
The Infectious Disease Society of America (IDSA) estimates that the
spike proteins that were generated by COVID-19 vaccines last up to a few weeks, like other proteins made by the body. The immune system quickly
identifies, attacks and destroys the spike proteins because it
recognizes them as not part of you. This "learning the enemy" process is
how the immune system figures out how to defeat the real coronavirus. It
remembers what it saw and when you are exposed to coronavirus in the
future it can rapidly mount an effective immune response.
However, in a paper published in Clinical Infectious Diseases (Swank 2023), researchers reported detecting a fragment of
SARS-CoV-2 in blood samples from long COVID sufferers up to a year after
their original infection. The fragment is a spike protein, one of the
protrusions around the outside of SARS-CoV-2 that give this coronavirus
its namesake corona, or crownlike appearance. During an initial COVID
infection, the spike protein typically breaks off into smaller pieces
when it penetrates human cells, but the spike proteins observed in this
study were still in one piece.
Although the research on nattokinase and its effect on COVID-19 is still in
its infancy, the ability of nattokinase to degrade spike proteins combined
with its anti-clotting properties makes it an exciting topic for further
study.
Some researchers and clinicians theorize that symptoms of
long COVID may be at least partially due to the blockage of vessels by
microclots, and that the spike protein might be the trigger—which is
supported by a recent
Harvard Medical School study. If this is the case, nattokinase could be a potential treatment for those
suffering from long COVID and its extensive list of symptoms.
Nattokinase’s
anti-clotting prowess and ability to dissolve spike proteins could also be
helpful with the clotting problems many doctors have observed in those who
took the vaccine, and could be a way to dissolve those blood clots before
they can do irreparable damage to tissues and organs.
FLCCC protocols
The Front Line COVID-19 Critical Care Alliance has developed protocols aimed at:
Patients should push their doctors to refer them to clinical trials, and when that is not feasible, then empiric therapy can be pursued. It is important to realize that in the absence of completed large randomized placebo controlled randomized trials, which are easily 5 or more years away in the future, no therapeutic claims can be made. In the meantime we must be perceptive as patients and open-minded as clinicians to come up with reasonable approaches that can be used to help those sick now with post-COVID syndromes.
The Wellness Company's acclaimed Spike Support Formula contains scientifically-researched
ingredients, including nattokinase, black seed oil, green tea extract and
selenium.
These ingredients are known for their ability to
dissolve spike protein, prevent it from binding to cells, and repair
tissue.
Recommended to maintain daily health for anyone exposed
to COVID, vaccines, or shedding – and may help your body repair itself and
remain at optimal health.
Where to buy Spike Support Formula: Spike Support Formula is available on The Wellness Company's
website. Here is the link: Spike Support Formula (Long Haul Formula)
Note: To get 10% OFF, please use this coupon code: ONEDAYMD
Base Spike Detox According to Dr Peter McCullough (in a Twitter post): Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. CLICK HERE FOR THE COMPLETE PAPER > Published on November 21, 2023 in Cureus (PubMed - November 2023) I have arrived, based on the emerging scientific literature and my clinical observation, that three OTC products are essential as a triple base combination: Nattokinase 2000 FU (100 mg) twice a day Bromelain 500 mg once a day Nano/Liposomal Curcumin 500 mg twice a day Additional products can be added, including NAC, IVM (Ivermectin), HCQ (Hydroxychloroquine), fluvoxamine, low-dose naltrexone, and blood thinners, depending on the clinical evaluation and the sy
Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough Protocol 2022 Updates: Double blind randomized controlled trial of saline solution gargling and nasal rinsing in COVID infection (Nov 2023) What really killed COVID-19 patients: It wasn't a cytokine storm, suggests study (2023) Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the pri
Well-respected North Texas cardiologist, Dr. Peter McCullough has impeccable academic credentials. He's an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough et al. Reviews in Cardiovascular Medicine, 2020 McCullough Protocol 2022 Updates: How to Detox Spike Protein from Body (November 2023) Paxlovid for Vaccinated or Unvaccinated Adult Outpatients with Covid-19 (NEJM April 2024) Omicron variant XBB found to be resistant to monoclon
Treatment should start based on clinical suspicion as soon as possible, preferably within the first 3 days of symptoms. Perform PCR testing, but do not withhold treatment pending results. 'Early' treatment will make significant difference in outcome as opposed to late treatment. To assist all who are having difficulty finding pharmacists to fill prescriptions for ivermectin or hydroxychloroquine (Plaquenil) for preventing or treating COVID-19, check out Find a Pharmacy to fill Ivermectin (US). Related: How can I get Ivermectin? See the directory of professionals in US below. Directory of Doctors (by State) Prescribing Effective Outpatient COVID-19 Therapy USA MULTIPLE STATES (Telemedicine or online consultation) The Wellness Company ( twc.health ) Medical Specialty: Family Medicine, Functional Medicine Supported Protocols: I-PREVENT (COVID Protection), I-CARE (Early at-home treatment), I-RECOVER (Lo
Over the last three years, the COVID-19 pandemic has transformed almost every aspect of our lives before we've had time to stop and question it. Although no official definition exists for post-COVID-vaccine syndrome, a temporal correlation between a patient receiving a COVID-19 vaccine and beginning or worsening of clinical manifestations is sufficient to diagnose as a COVID-19 vaccine-induced injury, when the symptoms are unexplained by other concurrent causes. Dr. Paul Marik and Dr. Pierre Kory are pleased to introduce the I-RECOVER: Post-Vaccine Treatment protocol, designed to help people who have experienced adverse symptoms after a COVID vaccine. Kory and Marik are both part of the FLCCC, which was founded in 2020 to share early treatment protocols for COVID-19. Kory is an ICU specialist, triple board certified in internal medicine, critical care and pulmonary medicine. He now runs a private tele-health practice specializing in the treatment
Is povidone iodine the next ivermectin or hydroxychloroquine? Is there any evidence that povidone iodine can treat COVID-19? Iodine 1% Nasal Spray is part of the FLCCC I-CARE early treatment protocol : Nasal spray with 1% povidone-iodine: 2-3 times a day. Do not use for more than 5 days in pregnancy. If 1% product is not available, dilute the more widely available 10% solution and apply 4-5 drops to each nostril every 4 hours. Use 1 % povidone iodine commercial product as per instructions 2–3 x daily. If 1 %-product not available, must first dilute the more widely available 10 %-solution. To make 1% povidone iodine concentrated solution from 10% povidone iodine solution, one dilution method is as follows: – First pour 1½ tablespoons (25ml) of 10% povidone/ iodine solution into a nasal irrigation bottle of
As of June 2024, more than 35 studies on the topic of zinc and COVID-19 ( c19zinc.com ) (constantly updated) and more than 10 studies on quercetin and COVID-19 have been published ( c19quercetin.com ). Dr. Zelenko’s main hypothesis based on the data showing that early intervention and treatment of high-risk patients with COVID-19 results in significantly few hospitalizations and deaths. This treatment regimen involving zinc, low-dose hydroxychloroquine, and azithromycin (published in the International Journal of Antimicrobial Agents ) is also apparently known as, “The Zelenko Protocol.” Quercetin and Zinc The Zelenko Covid-19 Protocols was developed by Dr Vladimir Zelenko. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of COVID-19, or can actually treat the disease once it has been diagnosed. Quercetin is a natural antihistamine a
SELF-HELP without a Doctor ( source ) Zinc 50 mg daily (can take half twice daily if upset stomach) Quercetin 500 mg twice a day three times a day if sick (switch to HCQ/IVM if available) Vitamin D3 40,000-50,000 for five days Melatonin 5 mg - 20 mg nightly for 14 days stomach) Pepcid 40-80 daily 14 days – women or Cimetidine 400 daily -men Full Aspirin (325 mg) daily one month N acetyl cysteine (NAC) Up to 2000-2400 mg 1-2 days, then 1000-1200 mg for a week Treatment: Latest Prescriptions ( source ) Monoclonal Antibodies: outpatient, FDA approved, early treatment, within 10 days Only. Note and Update: Omicron variant XBB found to be resistant to monoclonal antibody treatments ( New England Journal of Medicine . Dec 2022) HCQ 200 mg twice a day 7 days or IVM (weight based 0.4/kg) 20-36 mg daily 2-5 days Fenofibrate (Tricor – anti-lipid) 145 mg daily (inflammatory/cytokine phase. Antioxidant) Cyproheptadine (Periactin – antihistamine) 4 mg BID for 14 days (cytokine phase) D
The Front Line COVID-19 Critical Care (FLCCC) Alliance was initially formed as a working group during the early COVID-19 pandemic days in response to multiple early reports of COVID patients with an inexplicably high need for prolonged mechanical ventilation and an excessive death rate. Based on rapidly emerging clinical trials evidence, the FLCCC team has developed the I-MASK+ protocol ( is now divided into I-Prevent and I-Care protocols ) for prophylaxis and at home treatment of early stage COVID-19. Quercetin, zinc and a number of nutrients and drugs are part of this protocol, not only for critical care but also for prophylaxis and mild disease being treated at home. This article, we will dive deeper to provide the scientific background, related references and rationale of the FLCCC protocols. FLCCC ( Front Line COVID-19 Critical Care) Protocols I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19 was designed for use as a prevention and in early outpatien
Dr Peter McCullough's Spike Detox Protocol (Substack) According to Dr Peter McCullough's substack article : For several weeks I have been messaging the scientific community and the public about an approach addressing the burden of SARS-CoV-2 Spike protein in tissues and organs in the human body that is largely responsible for post-COVID and vaccine injury syndromes. No therapeutic claims can be made since large, prospective, double-blind randomized, placebo-controlled trials have not been completed on any of the compounds mentioned in this paper. I checked clinicaltrials.gov and no such trials have been planned. The Biden HHS US Action Plan for Long-COVID Research has pumped a billion dollars into long-COVID research and no new therapies have emerged. HHS, NIH, CDC, FDA have not recognized the larger issue of vaccine damage to the body. At three and one half years into the pandemic and two and a half years into the COVID-19 vaccine debacle, myself and my clinic partners formul
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