Formerly The COVID Advisor — evidence-based analysis of Long COVID, immune injury, and post-viral disease
Dr Peter McCullough: Spike Protein Exhausts Cardiomyocyte Mitochondria
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One of the most common features of long-COVID syndrome is post-exertional malaise. Even athletes tell me the smallest workout leaves them completely spent, unable to function for several hours.
Nakahara et al demonstrated that the hearts of those vaccinated almost always have abnormal PET scans demonstrating a shift from free fatty acids to 18-flourodeoxyglucose indicative of a fundamental cellular change that has occurred as a result of the vaccine Spike protein. The subcellular organelle responsible for energy generation is the mitochondria.
Van Huynk et al have demonstrated in cultured human cardiomyocytes, that the S1 segment of the Spike protein at 72 hours essentially exhausts the mitochondria. These subcellular organelles become fatigued, change their molecular functions, and even begin to undergo fission into fragments. No wonder people feel so bad all over with long-COVID!
Huynh TV, Rethi L, Lee TW, Higa S, Kao YH, Chen YJ. Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19. Cells. 2023 Mar 11;12(6):877. doi: 10.3390/cells12060877. PMID: 36980218; PMCID: PMC10046940.
We understand that McCullough Protocol Base Spike Detoxification is essential in treating long-COVID allowing cells to recover normal mitochondrial function. Those with very high Spike concentrations reflected by elevated Spike antibody titers > 1000 units/ml (Roche Elecsys assay) will likely require a full year or more of detoxification.
While undergoing this process, a supplement Dr Peter McCullough commonly recommend to address the symptoms of long-COVID including lack of energy and post-exertional malaise is Elevated Energy from The Wellness Company. If well tolerated, two capsules twice a day can be taken as empirically. While no therapeutic claims can be made, it is reasonable to consider this product for a boost in energy that will help on the road to recovery.
Base Spike Detox According to Dr Peter McCullough (in a X/Twitter post): Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. I have arrived, based on the emerging scientific literature (1) and my clinical observation, that three OTC products are essential as a triple base combination: Nattokinase 2000 FU (100 mg) twice a day Bromelain 500 mg once a day Nano/Liposomal Curcumin 500 mg twice a day Related: Nattokinase, Bromelain and Curcumin from The Wellness Company Additional products can be added, including NAC, IVM (Ivermectin), HCQ (Hydroxychloroquine), fluvoxamine, low-dose naltrexone, and blood thinners, depending on the clinical evaluation and the syndrome. The therapeut...
Dr. McCullough explained that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. He cited more than 300 papers documenting spike deposits in the heart, brain, and vascular tissue, relating these findings to post‑vaccine myocarditis, strokes, and clotting disorders. A chief diagnostic ste...
Dr. Peter McCullough is an internist, cardiologist, epidemiologist, a full professor of medicine at Texas A&M College of Medicine in Dallas, USA. He also has a master's degree in public health and is known for being one of the top five most-published medical researchers in the United States and is the editor of two medical journals. McCullough Protocol 2022 Updates: Double blind randomized controlled trial of saline solution gargling and nasal rinsing in COVID infection (Nov 2023) What really killed COVID-19 patients: It wasn't a cytokine storm, suggests study (2023) Everyone is familiar with nasal and oral swab testing for COVID-19. It should be obvious the virus is replicating in the nose, and with Omicron, the speed of replication has become much greater than the pr...
Can you remove spike proteins from your body? Dr. Paul Marik and Dr. Pierre Kory are pleased to introduce the I-RECOVER: Post-Vaccine Treatment protocol, designed to help people who have experienced adverse symptoms after a COVID vaccine. Kory and Marik are both part of the FLCCC*, which was founded in 2020 to share early treatment protocols for COVID-19. Kory is an ICU specialist, triple board certified in internal medicine, critical care and pulmonary medicine. He now runs a private tele-health practice specializing in the treatment of COVID-19, so-called "long-COVID" and post-vaccine syndrome. *The FLCCC Alliance is now the Independent Medical Alliance Note that there are significant overlaps between the symptoms and features of long COVID/long-hauler syndrome and post-vaccine syndrome. However, a number of clinical features appear to be characteristic of post-vaccine syndrome; most notably, severe neurological symptoms appear to be more common following vaccination. To c...
Dr. McCullough explained (1) that the spike protein is an engineered, synthetic molecule roughly 1,200 amino acids long and resistant to degradation by the body’s normal proteases. He described how the protein was modified in laboratory settings (notably at the Wuhan Institute of Virology) to tightly bind to the ACE2 receptor, which is found throughout the body—in the lungs, heart, endothelium, kidneys, and brain. Because this receptor regulates angiotensin metabolism, older individuals with fewer ACE2 sites catabolize the spike less efficiently, leading to worse outcomes. Whether introduced by infection or by genetic‑code‑based vaccines, McCullough asserted, the persistent spike damages tissues directly and through chronic inflammation, micro‑clotting, and autoimmune cross‑reactivity. He cited more than 300 papers documenting spike deposits in the heart, brain, and vascular tissue, relating these findings to post‑vaccine myocarditis, strokes, and clotting disorders. A chief diagnostic...
A Guide to Diagnosing and Managing Influenza and Respiratory Syncytial Virus (RSV) Infections in Adults In adult patients, COVID-19 (Omicron variant), influenza, and RSV present with similar symptoms and can, therefore, be difficult to distinguish. This guide aims to help diagnose and treat Influenza and Respiratory Syncytial Virus (RSV). Update: Oseltamivir Treatment vs Supportive Care for Seasonal Influenza Requiring Hospitalization (JAMA 2025) For advice on how to protect yourself against infection, see I-PREVENT: COVID, Flu and RSV Protection Protocol . For treatment of COVID-19, see I-CARE: Early COVID Treatment Protocol . For treatment of Post Vaccine Complications, see I-RECOVER: Post Vaccine Treatment . Update: Added Minocycline (Jan 2023 update) Note that there are two I-Care Protocols; the I-Care Covid protocol to treat Covid and this protocol, I-Care Flu protocol. About this Protocol The information in this document is our recommended approach to COVID-19 ...
Over the last three years, the COVID-19 pandemic has transformed almost every aspect of our lives before we've had time to stop and question it. Although no official definition exists for post-COVID-vaccine syndrome, a temporal correlation between a patient receiving a COVID-19 vaccine and beginning or worsening of clinical manifestations is sufficient to diagnose as a COVID-19 vaccine-induced injury, when the symptoms are unexplained by other concurrent causes. Dr. Paul Marik and Dr. Pierre Kory are pleased to introduce the I-RECOVER: Post-Vaccine Treatment protocol, designed to help people who have experienced adverse symptoms after a COVID vaccine. Kory and Marik are both part of the FLCCC ( The FLCCC Alliance is now the Independent Medical Alliance ), which was founded in 2020 to share early treatment protocols for COVID-19. Kory is an ICU specialist, triple board certified in internal medicine, critical care and pulmonary medicine. He now runs a priva...
Treatment should start based on clinical suspicion as soon as possible, preferably within the first 3 days of symptoms. Perform PCR testing, but do not withhold treatment pending results. 'Early' treatment will make significant difference in outcome as opposed to late treatment. Related: How can I get Ivermectin? See the directory of professionals in US below. Directory of Doctors (by State) Prescribing Effective Outpatient COVID-19 Therapy USA MULTIPLE STATES (Telemedicine or online consultation) The Wellness Company ( twc.health ) Medical Specialty: Family Medicine, Functional Medicine Supported Protocols: I-PREVENT (COVID Protection), I-CARE (Early at-home treatment), I-RECOVER (Long COVID and Post-Vaccine treatment) Dr. Miguel Antonatos (IVM) (855) 767-8559 https://text2md.com (States: AL, AZ, CO, FL, GA, IA, ID, IL, KS, KY, MD, ME, MI, MN, MS, ND, NE, NJ, NV, OK, SC, SD, TN, UT, VT, WA, WI, WV) ...
For years, clinicians and patients have described a disturbing pattern — cancers appearing suddenly, growing at unexpected speed, or diseases thought stable returning aggressively within weeks or months. A sudden rise in younger people with early onset cancers which are more aggressive with more (and unusual) genetic change has been increasingly noted - colorectal, breast and GI tract cancers seem to lead the way. Some called them “turbo cancers”. In oncology, the phenomenon is known as hyper-progression: cancers that accelerate far more rapidly than expected. Early on, these reports were ignored. They surfaced as scattered cases — isolated anecdotes that were easy to dismiss. One of the first to speak publicly was Belgian immunologist Michel Goldman, whose story was published in The Atlantic in 2022. He believed the Covid-19 vaccine may have accelerated his lymphoma. Shortly after vaccination and boosting, he developed swollen lymph nodes, fatigue and night sweats. Imaging revealed ...
The Front Line COVID-19 Critical Care (FLCCC*) Alliance was initially formed as a working group during the early COVID-19 pandemic days in response to multiple early reports of COVID patients with an inexplicably high need for prolonged mechanical ventilation and an excessive death rate. *The FLCCC Alliance is now the Independent Medical Alliance Based on rapidly emerging clinical trials evidence, the FLCCC team has developed the I-MASK+ protocol ( is now divided into I-Prevent and I-Care protocols ) for prophylaxis and at home treatment of early stage COVID-19. Quercetin, zinc and a number of nutrients and drugs are part of this protocol, not only for critical care but also for prophylaxis and mild disease being treated at home. This article, we will dive deeper to provide the scientific background, related references and rationale of the FLCCC protocols. December 2025 Update: The Stratus Variant (XFG): Symptoms, Global Spread, and Impact in Late 2025 FLCCC ( ...
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