5 Best Zinc Ionophore Supplements of 2022
Quercetin, Hydroxychloroquine, green tea extract, Zinc and black seed oil are among the handful of COVID-19 treatments that are being studied as candidates that might influence the outcome in the prevention and management of COVID-19. Hydroxychloroquine, Ivermectin, Quercetin and EGCG (EpiGalloCatechin Gallate) are all zinc ionophores. Meaning they all transport zinc into the cells.
It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA dependent RNA polymerase (PubMed 2010). The COVID-19 virus is a single stranded RNA (RiboNucleicAcid) virus and requires the RNA polymerase to replicate.
Other single stranded RNA viruses include Flu virus, RSV and dengue. They may use similar pathways for replication i.e. RNA dependent RNA polymerase (RDRP) to make copies of their genome.
We will dive deeper into the science for each of the above treatment and supplement.
There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.
Based on rapidly emerging clinical trials evidence, the FLCCC team has developed the I-MASK+ protocol for prophylaxis and at home treatment of early stage COVID-19.
- Prevention: Quercetin (93%) vs Hydroxychloroquine (32%)
- Early Treatment: Hydroxychloroquine (63%) vs Quercetin (38%)
Excessive doses may interfere with copper absorption, which could negatively affect your immune system as it can cause copper deficiencies, blood disorders, impair the absorption of antibiotics and potentially permanent nerve damage or loss of smell.
3. Green Tea Extract - EGCG (EpiGalloCatechin Gallate)
“EGCG showed a very high binding affinity and a low inhibition constant among all the phytoconstituents screened, especially in the case of 6vw1, which is a potential target of SARS-CoV-2,” the paper found.
“EGCG exhibited better binding with the viral proteins and hence, is expected to show better antiviral activity than the reference drugs, remdesivir and chloroquine,” it added.
It is important to remember, though, that by itself, EGCG is both unstable and bio-unavailable unless coupled with nutrients like zinc that studies show help to maximize its transport into cells.
4. Black Seed Oil (Nigella Sativa)
- Proliferation and activation of natural killer cells, macrophages, neutrophils, and T and B cells
- Mediating protection against reactive oxygen species produced during an inflammatory response
- Stopping recombinant RNA dependent RNA polymerase activity needed to replicate SARS-CoV-2
- Inhibiting replicase processing
Research has identified several zinc ionophores, including chloroquine, hydroxychloroquine, quercetin and EGCG. Scientists have suggested that several of the terpenes in black seed oil, such as nigellimine, are similar in structure to chloroquine. They hypothesize that this may mean they can function in a similar manner as a zinc ionophore.
5. Is Turmeric a zinc ionophore?
Curcumin, a yellow carotenoid from turmeric, is well known for its anti-inflammatory and free radical-scavenging effects.
There are more than 15 studies of curcumin in COVID-19 published. And the results are promising.
Curcumin has also been demonstrated (Ref) to suppress several inflammatory cytokines and mediators of their release such as tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and nitric oxide synthase.
Does Zinc Ionophore require a prescription?
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- Wear protective face mask. This is to protect not only yourself but others.
- Abundant evidence suggests that eating whole in fruits, vegetables and whole grains—all rich in networks of naturally occurring antioxidants and their helper molecules—provides protection against free radicals.
- Getting Enough Sleep
- Avoid Sugar, red meat and processed foods.
- Don't smoke.
- Take steps to avoid infection, such as washing your hands frequently and cooking meats thoroughly.
- Try to minimize stress.
- Drink enough water to keep your body hydrated.
- Avoid excess alcohol.
- Avoid crowded areas.
- Regular physical activity (outdoor activities may not be allowed in countries with 'lock-down').
- Consult your nearest local healthcare provider if you have any doubt.