The COVID Advisor

Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 (PASC), affects millions worldwide, manifesting as persistent symptoms including fatigue, cognitive impairment, and multi-organ dysfunction. This systematic review synthesizes evidence on the role of the SARS-CoV-2 spike (S) protein in long COVID pathophysiology, focusing on mechanisms such as persistent inflammation, endothelial dysfunction, and neuroinflammation. We searched major databases using keywords related to "SARS-CoV-2 spike protein," "long COVID," and "post-acute sequelae," identifying 76 relevant studies published up to August 2025. Key findings indicate that persistent S protein, detected in tissues up to 4 years post-infection, drives chronic inflammation via TLR4 activation and cytokine dysregulation (1, 2). Therapeutic targets include S protein-neutralizing agents and autophagy enhancers. This review highlights the need for longitudinal studies to confirm...

Can you test for spike protein in your body or blood? The short answer: it’s complicated. The better question: should you? Most of you will know “the spike protein” as the now infamous culprit behind much of the harm caused to long COVID and long vax sufferers. If you’ve found yourself wondering how much of that nasty stuff you might have in your system, you are not alone. Given the current spotlight on the spike protein, it’s no wonder it’s on everyone’s mind: Increased Awareness:  With the wealth of new studies and discussions, public awareness about the spike protein’s role has surged. Shedding  Phenomenon:  Recent insights into how the spike protein can be shared among individuals have heightened concerns. As a result, more than a few people wonder if you can test for the spike protein. In this post, we’ll set the record straight.  Can You Test For Spike Proteins? If you asked, “Is there a blood test for spike protein?” the...

Overview A new COVID-19 variant, identified as NB.1.8.1, has recently emerged and is drawing international attention due to its increasing prevalence, particularly in China, and its detection in the United States and other countries. September 2025 Update: The Stratus Variant (XFG): Symptoms, Global Spread, and Impact in Late 2025 1. Emergence and Spread of NB.1.8.1 Origin and Detection: NB.1.8.1 was first identified as a significant driver of rising COVID-19 cases in China. The U.S. Centers for Disease Control and Prevention (CDC) confirmed its presence in the United States, though as of late May 2025, fewer than 20 cases had been reported domestically. Global Spread: The World Health Organization (WHO) and multiple health authorities have noted that NB.1.8.1 is now spreading worldwide, with cases reported in several countries. Its rapid dissemination has raised concerns about potential increases in COVID-19 cases in various regions. 2. Variant Characteristics Genetic Profile: NB.1.8....