The COVID Advisor

Abstract Background: Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), continues to affect millions globally. Persistent symptoms include fatigue, cognitive impairment, dyspnea, autonomic dysfunction, and multi-organ involvement. Objectives: To summarize the latest 2026 research on biological mechanisms, clinical features, risk factors, and treatment approaches for Long COVID. Methods: Literature review of peer-reviewed publications, government reports, and large cohort studies from 2023–2026, using PubMed, PMC, NIH RECOVER data, and major news outlets reporting verified research. Results: Key mechanisms identified include persistent inflammation, microvascular thrombosis, immune dysregulation, autonomic nervous system involvement, and in some patients, neurodegenerative protein elevations. Reinfection and pre-existing comorbidities are significant risk factors. Current management remains symptom-focused and multidisciplinary. ...

Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms such as fatigue, dyspnea, cognitive impairment, and dysautonomia. Interest in nutraceuticals —dietary supplements, herbal extracts, and vitamins—has grown as potential adjuncts to symptom management. This review evaluates current clinical and preclinical evidence for commonly discussed nutraceuticals, including curcumin, N-acetylcysteine (NAC), omega-3 fatty acids, nattokinase, bromelain and probiotics, and contrasts them with established evidence-based clinical management. While some nutraceuticals demonstrate mechanistic plausibility for anti-inflammatory or antioxidant effects, high-quality clinical trial evidence supporting their efficacy in Long COVID is largely absent. Clinicians and patients should consider nutraceuticals as adjunctive therapy under supervision , prioritizing guideline-recommended interventions such as multidisciplinary care, rehabilitation, and s...

Abstract Persistent symptoms following SARS‑CoV‑2 infection, collectively termed Long COVID or post‑acute sequelae of COVID‑19 (PASC), remain a significant clinical challenge. One proposed biological mechanism involves prolonged presence of SARS‑CoV‑2 spike protein or viral RNA fragments post‑infection. Additional questions concern spike protein dynamics after COVID‑19 vaccination. This review synthesizes current peer‑reviewed evidence on spike protein detection after natural infection and vaccination, clarifying clinical context, limitations, and implications. Data indicate that SARS‑CoV‑2 spike protein and/or fragments can be detected in circulation or tissues up to a year or longer post‑infection, especially in PASC cohorts, whereas vaccine‑derived spike is typically transient and associated with rapid immune clearance. Mechanistic and clinical significance remains an area of ongoing research. Keywords: SARS‑CoV‑2, spike protein, long COVID, PASC, post‑vaccination, antigen persiste...

More than four years following the emergence of COVID-19, a subset of individuals experience persistent, multisystem symptoms extending beyond three months post-infection or post-exposure to mRNA-based COVID-19 vaccines.  This condition, historically termed "Long COVID," has recently been redefined by some researchers as "Post-Spike Syndrome" (PSS) or "SPIKEOPATHY," emphasizing the pathogenic role of the SARS-CoV-2 Spike protein derived from both viral infection and mRNA vaccination.  This article summarizes the most recent scientific findings and clinical advances to help patients and healthcare providers better understand and manage this complex condition. Update: Long COVID in 2026 : Integrative Biological Insights and Therapeutic Considerations Latest Research Insights on Long COVID Immune System Markers and Genetic Risk Factors A recent clinical study led by Cardiff Metropolitan University and Cwm Taf Morgannwg University Health Board identified eleva...

Since 2023, thousands of Long COVID sufferers worldwide have quietly added one inexpensive compound to their recovery stacks with dramatic results: pharmaceutical-grade DMSO (dimethyl sulfoxide). What started as scattered case reports on X and Reddit has grown into one of the largest patient-driven treatment datasets in post-viral illness history. Why DMSO Is Working When Almost Everything Else Has Failed 1. Chest Pain & Shortness of Breath Often Improve in 3–10 Days Sources/Anecdotes: X Post by  @VigilantFox   (July 28, 2025):  Describes COPD patients (often linked to long COVID) tied to oxygen tanks who could breathe without supplemental oxygen after a week of DMSO nebulizer. One bedridden patient walked 30 minutes on an elliptical. Link:   https://x.com/VigilantFox/status/1986121709863256352  (Thread on DMSO for lung recovery; includes video testimonial of Daniel with stage 3 COPD improving in days). Similar stories:  "People using DMSO for pain were...